PRSS2 Antibody

Code CSB-PA018814LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Mouse heart tissue, Mouse liver tissue, Mouse brain tissue, Mouse kidney tissue
    All lanes: PRSS2 antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 27 kDa
    Observed band size: 27 kDa

  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA018814LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PRSS2 Polyclonal antibody
Uniprot No.
Target Names
PRSS2
Alternative Names
Anionic trypsinogen antibody; EC 3.4.21.4 antibody; MGC111183 antibody; MGC120174 antibody; Protease serine 2 preproprotein antibody; Protease; serine; 2 (trypsin 2) antibody; Protease; serine; 2 antibody; Protease; serine; 2; preproprotein antibody; Prss2 antibody; Serine protease 2 antibody; TRY2 antibody; TRY2_HUMAN antibody; TRY8 antibody; TRYP2 antibody; Trypsin 2 antibody; Trypsin II antibody; Trypsin-2 antibody; Trypsinogen 2 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Trypsin-2 protein (24-247AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PRSS2 Antibody (Product code: CSB-PA018814LA01HU) is Non-conjugated. For PRSS2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA018814LB01HU PRSS2 Antibody, HRP conjugated ELISA
FITC CSB-PA018814LC01HU PRSS2 Antibody, FITC conjugated
Biotin CSB-PA018814LD01HU PRSS2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

CUSABIO's product CSB-PA018814LA01HU is a PRSS2 polyclonal antibody raised in the rabbit against the recombinant human PRSS2 protein (24-247AA). It exists as the unconjugated IgG isoform. It is purified by protein G and reaches up to 95% in purity. And it shows reactivity with human and mouse samples. This PRSS2 antibody can recognize PRSS2 protein in ELISA, WB, and IHC applications. The PRSS2 protein is found at high levels in pancreatic juice and is upregulated in human pancreatitis and chronic alcoholism.

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Target Background

Function
In the ileum, may be involved in defensin processing, including DEFA5.
Gene References into Functions
  1. evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis PMID: 26110235
  2. PRSS2 single nucleotide polymorphism associated with the development of alcoholic pancreatitis. PMID: 25253127
  3. Serum trypsinogen-2 is associated with pancreatic cancer and pancreatitis. PMID: 25916077
  4. trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms. PMID: 22909050
  5. Elevation of urine trypsinogen 2 is an independent risk factor for pancreatic fistula after pancreaticoduodenectomy. PMID: 22357509
  6. Report a simple, rapid, easy, and noninvasive urinary trypsinogen-2 test can diagnose or rule out most cases of acute pancreatitis. PMID: 22481290
  7. Data show that urinary trypsinogen-2 dipstick test is a useful test for early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21946810
  8. results suggest that trypsinogen-2 is a more sensitive marker than amylase, and it can be useful in early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21792081
  9. A genetic variant of PRSS2 may contribute to the low prevalence of pancreatitis in primary hyperparathyroidism patients. PMID: 20625975
  10. Hyperexpression of the PRSS2 gene is associated with pancreatic cancer. PMID: 20428826
  11. there was a borderline statistically significant association between pancreatic cancer and HAT/HCT but no association between pancreatic cancer and HAT, HCT. PMID: 20484960
  12. Urine trypsinogen-2 test may be an important diagnostic tool in excluding the diagnosis of acute pancreatitis; it has a negative predictive value. PMID: 20517765
  13. Results do not support the urinary trypsinogen-2 dipstick test (UTDT) to replace standard plasma amylase for the diagnosis of AP, however, the test demonstrated an adequate sensitivity to be used for rapid early screening of AP in daily clinics. PMID: 19752771
  14. Results indicate that up-regulation of anionic trypsinogen in pancreatic diseases does not affect physiological trypsinogen activation, but significantly limits trypsin generation under potential pathological conditions. PMID: 12709065
  15. High levels of pulmonary trypsin-2 may be associated with the development of bronchopulmonary dysplasia in preterm infants. PMID: 12949286
  16. G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis PMID: 16699518
  17. Our results suggest that serum trypsinogen-2 is a most useful marker for diagnosing patients with cholangiocarcinoma, and it is superior to serum CA19-9 and CEA. PMID: 17640760
  18. Co-localization of trypsin-2 and MMP-9 resulted in intracellular proMMP-9 processing that represented fully or partially activated MMP-9. PMID: 18062964
  19. A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. PMID: 18362849
  20. A fusion with PRSS1 is associated with hereditary pancreatitis. PMID: 18461367
  21. primary role of trypsinogen sulfation in humans is to stimulate autoactivation of PRSS1 PMID: 18986305
  22. The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan. PMID: 19052022
  23. G191R PRSS2 is a rare allele in the Indian population and the data suggest a nonsignificant trend towards a protective effect from tropical calcific pancreatitis in Indians. PMID: 19077465

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Subcellular Location
Secreted, extracellular space.
Protein Families
Peptidase S1 family
Tissue Specificity
Expressed in Paneth cells, at the base of small intestinal crypts.
Database Links

HGNC: 9483

OMIM: 601564

KEGG: hsa:5645

UniGene: Hs.449281

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