Recombinant Human C-X-C motif chemokine 9 protein(CXCL9) (Active)

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Code CSB-AP000711HU
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Product Details

Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood T-lymphocytes is in a concentration range of 10- 100 ng/ml.
Target Names CXCL9
Uniprot No. Q07325
Research Area Immunology
Alternative Names C-X-C motif chemokine 9; chemokine (C-X-C motif) ligand 9; CMK; crg-10; CXCL9; CXCL9_HUMAN; gamma interferon induced monokine; Gamma-interferon-induced monokine; HuMIG; MIG; monokine induced by gamma interferon; monokine induced by interferon gamma; Monokine induced by interferon-gamma; SCYB9; Small inducible cytokine B9; small inducible cytokine subfamily B member 9; Small-inducible cytokine B9
Species Homo sapiens (Human)
Source E.coli
Expression Region 23-125aa
Complete Sequence TPVVRKGRCS CISTNQGTIH LQSLKDLKQF APSPSCEKIE IIATLKNGVQ TCLNPDSADV KELIKKWEKQ VSQKKKQKNG KKHQKKKVLK VRKSQRSRQK KTT
Mol. Weight 11.7 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
Gene References into Functions
  1. CXC chemokine ligand 9 promotes the progression of diffuse large B-cell lymphoma in a beta-catenin-dependent manner. PMID: 30130730
  2. CXCL9 level was significantly higher in alopecia areata patients compared with controls and with vitiligo patients PMID: 27863059
  3. CXCL9 may promote prostate cancer progression via inhibition of cytokines from T cells. PMID: 29901197
  4. High CXCL9 expression is associated with invasion and metastasis in tongue squamous cell carcinoma. PMID: 29286143
  5. MIG low in the tumor microenvironment can be used as potential indicators for the progression of non-small cell lung cancer PMID: 28375674
  6. the results of the current study revealed increased serum levels of MIG as a novel independent marker of poor prognosis in newly diagnosed patients with MM. PMID: 26999330
  7. High CXCL9 expression is associated with clear-cell renal cell carcinoma. PMID: 26910919
  8. Circulating CXCL9 serum levels are high in chronic Q fever patients and is a promising biomarker for the diagnosis of chronic Q fever. PMID: 28793883
  9. High urine CXCL9 level is associated with acute rejection in Histologically Stable Kidney transplant Recipients. PMID: 26694099
  10. CXCL9 expression in lesional macrophages implicates the skin as the source of circulating cytokines. CXCL9 is a promising biomarker of disease activity in morphea. PMID: 28450066
  11. significant correlation between serum levels and the severity of coronary artery disease, quantified by the Gensini score PMID: 28100872
  12. High CXCL9 plasma levels favour response to pegIFN alpha 2a and ribavirin in hepatitis C virus infected patients regardless of DPP4 activity. PMID: 26344576
  13. CXCL9 is a useful predictor of better clinical outcome in colorectal cancer patients. PMID: 26898419
  14. The mRNA expression and serum levels of CXCL9 were both increased. PMID: 26828996
  15. Data show that asymptomatic patients with unstable plaques exhibited higher levels of endothelial microparticles (EMPs), CXCL9 chemokine and stem cell growth factor; lymphocyte secreted C-type lectin (SCGF-beta) compared to those with stable plaques. PMID: 26564003
  16. congruent with the concept that inflammation plays a key role in the pathogenesis of LV dysfunction, MIG, IP10 and I-TAC add diagnostic accuracy over and beyond NT-pro BNP. PMID: 26506526
  17. Suggest that CD44 and CXCL9 may serve as predictive biomarkers to identify liver allograft recipients at risk for clinically significant acute graft rejection. PMID: 25950774
  18. Knock-down of CD44 resulted in an upregulation of mRNA expression of the chemokines CXCL9 and CXCL12, as well as their receptors CXCR3 and CXCR4. PMID: 24614402
  19. There were no significant differences in distribution of CXCL9 genotypes and alleles between rheumatoid arthritis patients and control group. PMID: 25702175
  20. This work confirms that OPN, CCL5 and CXCL9 plasma levels are higher in psoriasis patients and provides evidence that their higher levels are not a consequence of obesity. PMID: 25972108
  21. This inhibitory action of resveratrol was also observed for the cytokines-induced expression of chemokines CXCL9, CCL2 and CCL5. PMID: 25890876
  22. This paper suggests a role for Epithelial to mesenchymal cell transition in the pathogenesis of idiopathic pulmonary fibrosis and provides a novel mechanism for the inhibitory effects of CXCL9 on TGF-beta1-induced Epithelial to mesenchymal cell transition. PMID: 26268659
  23. The expression of TNF-alpha and CXCL9 in blood samples stimulated with a bacterial antigen distinguishes active tuberculosis patients from latent disease carriers and healthy controls. PMID: 25528189
  24. CXCL9 inhibits the proliferation of epithelial cells via phosphorylation of p70S6K, resulting in the excretion of TGF-beta as downstream mediator. CXCL9/CXCR3 interaction can exacerbate antineoplastic agent-induced intestinal damage. PMID: 25398650
  25. CXCL9 is involved in the invasion ability of hepatocellular carcinoma cells possibly through up-regulation of its potential effector PREX2. PMID: 25151370
  26. both bactericidal and cell-recruiting activities of MIG/CXCL9 are corrupted by P. aeruginosa through release of elastase, and this may contribute to impaired airway host defense in CF. PMID: 25115612
  27. Elevated IL-2R, IL-1RA, and CXCL9 are associated with shorter event-free survival in newly diagnosed follicular lymphoma, treated with chemoimmunotherapy. PMID: 25422100
  28. CXCL9 expression was low in control skin, mild in perilesional skin from slowly progressive vitiligo and high in progressive vitiligo. Such expression was found in the epidermal as well as the dermal infiltrate. PMID: 24438589
  29. study demonstrated that CXCL9 is associated with tumor burden and aggressiveness of NPC tumors and the serum level of this ligand may be useful as a prognostic indicator PMID: 24278236
  30. Higher circulating levels of CXCL-9 and -11 have been shown in non-pregnant autoimmune thyroiditis patients with a history of recurrent abortion as compared to both control groups PMID: 24351073
  31. In this study of human cryoglobulinemic glomerulonephritis we showed a striking expression of cytokine CXCL9, a classical macrophage activation marker, by the macrophages and possibly other cell types within the glomeruli. PMID: 24084359
  32. High urinary CXCL9 is associated with kidney transplant injury. PMID: 23968332
  33. CXCL9 associated with sustained virological response in chronic hepatitis B patients receiving peginterferon alfa-2a therapy. PMID: 24124595
  34. Plasma concentrations of CXCL9 are elevated at the onset of chronic graft-versus-host disease diagnosis, but not in patients with chronic graft-versus-host disease for more than 3 months. PMID: 24363401
  35. Collectively, our results show that a diverse milieu of chemokines is expressed in myocardium and valvular tissue lesions and emphasize the role of CXCL9/Mig in mediating T cell recruitment to the site of inflammation in the heart. PMID: 23417848
  36. Our study demonstrated that CXCL9 is associated with tumor burden and aggressiveness of OSCC tumors and serum level of this ligand may be useful as a prognostic indicator PMID: 23769451
  37. CXCL9 was increased in lung transplant lavage fluid during diffuse alveolar damage, acute rejection, and lymphocytic bronchiolitis. Elevated CXCL9 was associated with increased risk of chronic allograft dysfunction. PMID: 24063316
  38. Our study demonstrates in mixed cryoglobulinemia and hepatitis C vs controls: (i)high serum CXCL9 and CXCL11, significantly associated with the presence of active vasculitis; (ii) a strong relationship between circulating CXCL9 and CXCL11 PMID: 23527708
  39. The secretion of CXCL9 by activated T cells is also increasingly downregulated with increasing concentrations of bortezomib. PMID: 23179902
  40. Report high serum levels of CXCL9/TNF-alpha/interferon-gamma in patients with mixed cryoglobulinaemia and chronic hepatitis C. PMID: 22766105
  41. Intragraft CXCL9 mRNA has a functionally important role in T-cell activation in liver allograft and serves as biomarker for acute cellular rejection. PMID: 22889476
  42. CXCL9 is localized predominantly in the cytoplasm of breast cancer cells and prostaglandin E2 inhibits cytokine induced CXCL9 secretion. PMID: 22333315
  43. Malaria-infected primigravidae with placental CXCL9 levels in the lowest tertile gave birth to babies who weighed 610 g more than babies born to mothers with high CXCL9 levels. PMID: 22689822
  44. Elevated plasma levels of MIG are associated with inflammatory bowel disease with JCV infection. PMID: 22467521
  45. HSV-2 induces CXCL9 expression in human cervical epithelial cells by activation of p38-C/EBP-beta pathway PMID: 22586042
  46. Autophagy may be a crucial intracellular mechanism of Mig induction in response to HBV infection. PMID: 22580676
  47. Immunohistochemically, the lining synovium of Rheumatoid Aarthritis clearly expressed CXCL9 PMID: 22401175
  48. Elevated plasma levels of interferon-gamma and Cys-X-Cys chemokine receptor 3-binding chemokine CXCL9 are present in patients with thoracic aortic aneurysms. PMID: 21962843
  49. We found that urine CXCL9 and CXCL10 were markedly elevated in adults and children experiencing either AR or BKI (p = 0.0002), but not in stable allograft recipients PMID: 21812928
  50. We first show that circulating CXCL9 and CXCL11 are increased in patients with thyroiditis and hypothyroidism and are related to each other. PMID: 21470996
  51. Letter: Pretransplant serum CXCL9 levels failed to predict acute rejection in patients receiving basiliximab or alemtuzumab induction therapy. PMID: 21475065
  52. CXCL9 expressed by tumour stroma cells promotes the escape of the melanoma cells from tumour metastases. PMID: 21179030
  53. Expression of MIG mRNA after vaccination correlated inversely with malaria vaccine immunogenicity. PMID: 20838432
  54. A potent dose-dependent inhibition by PPARalpha-agonists was observed on the cytokines-stimulated secretion of CXCL9 in Graves disease and in primary thyrroid culture. PMID: 20810571
  55. CXCL9 may have a role in acute rejection and graft failure risk in kidney transplantation [commentary] PMID: 20456109
  56. CXCL9 may have a role in acute rejection and graft failure in kidney graft recipients PMID: 19929857
  57. higher expression in the genital mucosa than in the blood of HIV-1-infected women from Benin PMID: 19898927
  58. Data demonstrate that CXCL9 has immunomodulatory functions that are not mediated through a G-protein coupled receptor and may possess additional roles in host defenses against infection. PMID: 20038462
  59. The IFN-gamma inducible MIG protein behaves as a homing chemokine constitutively expressed in human brain microvascular endothelial cells and astrocytes. PMID: 12162873
  60. that IFNgamma stimulates the production of IP-10 and Mig in the SS ductal epithelium, and that IP-10 and Mig are involved in the accumulation of T cell infiltrates in the Sjogren syndrome salivary gland. PMID: 12384933
  61. A higher amount of MIG mRNA is expressed after exposure of keratinocytes to interferon-gamma, leading to migration of T cells from the dermis to the epidermis and representing a second step of chemotaxis following T cell recruitment from blood. PMID: 12847282
  62. Constitutive NF-kappaB activity is required for the induced gene expression of CXCL9 in tumour cell lines in response to IFNgamma. PMID: 12946268
  63. The chemokine CXCL9, usually associated with Th1 cells, is elevated in serum of patients with acute Syndenham's chorea. PMID: 15081261
  64. Serum Mig levels in atopic dermatitis patients were significantly higher than those in control subjects PMID: 15113590
  65. Increased expression of the interferon-induced angiostatic ELR- CXC chemokines is a feature of juvenile DM that parallels the degree of vasculopathy in patients with the disease PMID: 16200621
  66. This CXCR3 ligand has the ability to activate biochemical (e.g., PtdIns 3-kinase and MAP kinase activation) and functional events (actin reorganization) in intestinal myofibroblasts. PMID: 16210647
  67. Increased plasma monokine induced by gamma interferon (MIG) levels in daughters and sisters of primary biliary cirrhosis (PBC) patients demonstrates involvement of MIG interaction with its receptor CXCR3 as a familial risk factor for PBC. PMID: 16243485
  68. Both a Th1 chemoattractant (CXCL9) and Th2 chemoattractants, CCL17 and CCL22, cooperatively play a role in the development of autoimmune blistering disease. PMID: 16583210
  69. A novel innate defense mechanism against invasive bacteria on epithelial surfaces is reported in pharyngeal cells expressing. PMID: 17262710
  70. Data suggest atherosclerotic inflammation may be a trigger for sclerosis in calcified stenotic aortic valves through upregulation TGF-beta, VAP-1, MIG and Eotaxin3, which is only partially inhibited by previous statin therapy. PMID: 17490641
  71. During treatment of ulceretive colitis with corticosteroids CXCL1/CXCL9 were decreased. PMID: 17703315
  72. Data may contribute to a better understanding of the pathophysiology underlying Crohn's disease. PMID: 17892861
  73. In summary, both GGS (Streptococcus dysgalactiae subsp. equisimilis) and GAS (Streptococcus pyogenes) evoke MIG/CXCL9 expression but they differ in susceptibility to its antibacterial effects. PMID: 17975089
  74. Inflammatory chemokine CXCL9 triggers lymphocyte function-associated antigen-1 (LFA-1) adhesiveness in a RhoA-independent manner and without triggering integrin extension. PMID: 18292502
  75. finding a constitutive expression of MIG/CXCL9 in the male urogenital tracts suggests roles for this chemokine both in host defense and during early phases of fertilization PMID: 18338951
  76. primary renal disease showed significant increased levels of urinary CXCL8 and CXCL9 compared to controls PMID: 18413205
  77. Graves' disease patients who relapsed or went into remission had significantly different levels of CXCL9. PMID: 18415893
  78. HBx protein induced MIG expression in a dose-dependent manner PMID: 19157479
  79. positive correlation between ESAT6-induced IFNgamma and CXCL9 was present in all TB patients, but IFNgamma and CCL2 was only correlated in LNTB PMID: 19340290
  80. Report antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. PMID: 19344719

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Subcellular Location Secreted
Protein Families Intercrine alpha (chemokine CxC) family
Database Links

HGNC: 7098

OMIM: 601704

KEGG: hsa:4283

STRING: 9606.ENSP00000354901

UniGene: Hs.77367

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