CXCL9

CXCL9, also known as monokine induced by gamma interferon (MIG), is a CXC chemokine primarily secreted by activated macrophages, endothelial cells, and dendritic cells. It functions as a key chemoattractant for CXCR3-expressing immune cells, including T lymphocytes and natural killer cells, by binding to its cognate receptor CXCR3, thereby mediating immune cell recruitment to inflamed tissues.
CXCL9 participates in Th1-type immune responses and is involved in signaling pathways such as the JAK-STAT pathway, particularly downstream of IFN-γ. Dysregulation of CXCL9 is associated with autoimmune diseases like rheumatoid arthritis and multiple sclerosis, as well as infectious diseases and cancer. Its role in immune cell trafficking makes it a potential therapeutic target, with ongoing research exploring CXCL9/CXCR3 inhibitors for inflammatory disorders and modulators for cancer immunotherapy.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CXCL9 Antibody (CSB-PA06189A0Rb)

Validated Data

IHC image of CSB-PA06189A0Rb diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human monocyte interferon gamma inducing factor,MIG ELISA Kit (CSB-E09024h)

Validated Data

Code: CSB-E09024h

Size: 96T,5×96T,10×96T

Sensitivity: 9.75 pg/ml.

Detection Range: 39 pg/ml-2500 pg/ml.

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following CXCL9 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CXCL9 Antibodies

CXCL9 Proteins

CXCL9 ELISA Kits

CXCL9 Antibodies

CXCL9 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA09269A0Rb	Cxcl9 Antibody	Mouse	ELISA
CSB-PA09269D0Rb	Cxcl9 Antibody, Biotin conjugated	Mouse	ELISA

CXCL9 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA959979	CXCL9 Antibody	Human	IHC,ELISA
CSB-PA06189A0Rb	CXCL9 Antibody	Human	ELISA, IHC

CXCL9 Proteins

CXCL9 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP006252MO CSB-BP006252MO CSB-MP006252MO CSB-EP006252MO-B	Recombinant Mouse C-X-C motif chemokine 9 (Cxcl9)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP001131MO	Recombinant Mouse C-X-C motif chemokine 9 protein (Cxcl9), partial (Active)	E.coli
CSB-EP006252MO	Recombinant Mouse C-X-C motif chemokine 9 (Cxcl9)	E.coli

CXCL9 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP006252BO CSB-EP006252BO CSB-BP006252BO CSB-MP006252BO CSB-EP006252BO-B	Recombinant Bovine C-X-C motif chemokine 9 (CXCL9)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CXCL9 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-AP000711HU	Recombinant Human C-X-C motif chemokine 9 protein (CXCL9)	E.Coli
CSB-EP006252HU	Recombinant Human C-X-C motif chemokine 9 (Cxcl9)	E.coli
CSB-EP006252HUc7	Recombinant Human C-X-C motif chemokine 9 (Cxcl9)	E.coli