Recombinant Mouse C-C motif chemokine 5 protein(Ccl5) (Active)

In Stock
Code CSB-AP001241MO
Product Type Chemokine
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P30882
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered concentrated solution in 30 % Acetonitrile and 0.1 % TFA,Lyophilized
Alias MuRantes, Small-inducible cytokine A5, T-cell-specific protein RANTES
Species Mus musculus (Mouse)
Biological_Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T lymphocytes is in a concentration range of 1.0-10 ng/ml.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS
Research Area Immunology
Source E.coli
Gene Names Ccl5
Expression Region 24-91aa
Tag Info Tag-Free
Mol. Weight 7.9 kDa
Protein Description Full Length of Mature Protein
PubMed ID 1375672; 1376260; 7507961; 7513046; 10438970; 16141072; 15489334
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Function Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity T-cell and macrophage specific.
Database Links

KEGG: mmu:20304

STRING: 10090.ENSMUSP00000039600

UniGene: Mm.284248

Pathway Chemokine signaling pathway
TNF signaling pathway
NOD-like receptor signaling pathway
Toll-like receptor signaling pathway

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