CCL5 (Chemokine C-C motif ligand 5), also known as RANTES (Regulated on Activation, Normal T Expressed and Secreted), is a pro-inflammatory chemokine primarily secreted by T lymphocytes, platelets, and endothelial cells. It mediates immune cell recruitment by binding to G-protein-coupled receptors CCR1, CCR3, and CCR5, facilitating chemotaxis of monocytes, eosinophils, and memory T cells to inflammatory sites. CCL5 activates multiple signaling pathways, including JAK/STAT, MAPK, and PI3K/AKT, which regulate leukocyte migration, cytokine release, and tissue remodeling. Dysregulation of CCL5 is implicated in HIV progression (via CCR5 co-receptor competition), rheumatoid arthritis, atherosclerosis, and cancer metastasis. Therapeutic strategies targeting CCL5 or its receptors include the FDA-approved CCR5 antagonist maraviroc for HIV, while investigational anti-CCL5 monoclonal antibodies (e.g., Bertilimumab) and small-molecule inhibitors are in Phase II trials for autoimmune diseases and solid tumors. Recent studies also explore its dual role in tumor immunosuppression and angiogenesis modulation.
Recombinant Human C-C motif chemokine 5 (CCL5) (CSB-EP004800HUc7)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCL5 Antibody (CSB-PA05955A0Rb)
Validated Data
Western blot
All lanes: CCL5 antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 10 kDa
Observed band size: 70 kDa
The following CCL5 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CCL5 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA05955A0Rb | CCL5 Antibody | Human | ELISA, WB |
CSB-PA05955B0Rb | CCL5 Antibody, HRP conjugated | Human | ELISA |
CSB-PA05959A0Rb | CCL5 Antibody | Human | ELISA, WB |
CSB-PA040300 | CCL5 Antibody | Human,Mouse,Rat | IHC, ELISA |
CCL5 Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-YP004800GU CSB-EP004800GU CSB-BP004800GU CSB-MP004800GU CSB-EP004800GU-B |
Recombinant Guinea pig C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP004800HU CSB-BP004800HU CSB-MP004800HU CSB-EP004800HU-B |
Recombinant Human C-C motif chemokine 5 (CCL5) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP000871HU | Recombinant Human C-C motif chemokine 5 protein (CCL5) | E.Coli |
CSB-EP004800HUe0 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
CSB-EP004800HU | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
CSB-EP004800HUc7 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
CSB-EP004800HUg5 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
CSB-EP004800HUd7 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
CCL5 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP004800MO CSB-EP004800MO CSB-BP004800MO CSB-MP004800MO CSB-EP004800MO-B |
Recombinant Mouse C-C motif chemokine 5 (Ccl5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP001241MO | Recombinant Mouse C-C motif chemokine 5 protein (Ccl5) (Active) | E.coli |
CCL5 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP004800RA CSB-EP004800RA CSB-BP004800RA CSB-MP004800RA CSB-EP004800RA-B |
Recombinant Rat C-C motif chemokine 5 (Ccl5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP004800BO CSB-EP004800BO CSB-BP004800BO CSB-MP004800BO CSB-EP004800BO-B |
Recombinant Bovine C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP643672PI CSB-EP643672PI CSB-BP643672PI CSB-MP643672PI CSB-EP643672PI-B |
Recombinant Pig C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP808495DO CSB-EP808495DO CSB-BP808495DO CSB-MP808495DO CSB-EP808495DO-B |
Recombinant Dog C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP814163MOW CSB-EP814163MOW CSB-BP814163MOW CSB-MP814163MOW CSB-EP814163MOW-B |
Recombinant Macaca mulatta C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Sigmodon hispidus (Hispid cotton rat)
Code | Product Name | Source |
---|---|---|
CSB-YP842062SZK CSB-EP842062SZK CSB-BP842062SZK CSB-MP842062SZK CSB-EP842062SZK-B |
Recombinant Sigmodon hispidus C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-YP844627CA CSB-EP844627CA CSB-BP844627CA CSB-MP844627CA CSB-EP844627CA-B |
Recombinant Cat C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP847581HO CSB-EP847581HO CSB-BP847581HO CSB-MP847581HO CSB-EP847581HO-B |
Recombinant Horse C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL004800DO | Dog C-C motif chemokine 5(CCL5) ELISA kit | serum, plasma, tissue homogenates | 0.081 ng/mL |
CCL5 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E17375h | Human C-C motif chemokine 5 (CCL5/D17S136E/SCYA5) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 2.307 pg/mL |
CCL5 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E09256m | Mouse regulated on activation in normal T-cell expressed and secreted,RANTES ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
CCL5 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07398r | Rat regulated on activation in normal T-cell expressed and secreted/C-C motif chemokine 5 (RANTES/CCL5) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.039 ng/mL |