Recombinant Mouse protein C-C motif chemokine (Ccl17) (Active)

CCL17 (TARC/ABCD-2) is a key CCR4 ligand that drives Th2 cell recruitment and plays a central role in allergic inflammation, atopic dermatitis models, and tumor immune evasion studies in mice. This tag-free recombinant mouse CCL17, encompassing the full-length mature sequence (residues 24–93), demonstrates potent chemotactic activity on human T-lymphocytes at 1.0–10 ng/mL, providing a suitable basis for chemotaxis and migration assays, CCR4-dependent signaling pathway studies, and in vivo models of airway or skin inflammation. Endotoxin levels below 1.0 EU/μg minimize LPS-driven artifacts in sensitive immune cell assays, making this protein appropriate for T-cell polarization experiments, antibody validation as an ELISA or Western blot positive control, and use as a reference standard in cytokine detection platforms. Purity exceeding 97% by SDS-PAGE, combined with this stringent endotoxin control, satisfies the quality thresholds commonly required for both functional bioassays and quantitative immunoassay development.