Recombinant Rat C-X-C motif chemokine 2 protein(Cxcl2) (Active)

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Code CSB-AP001401RA
Product Type Chemokine
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Uniprot No. P30348
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias Cytokine-induced neutrophil chemoattractant 3, Macrophage inflammatory protein 2, MIP2
Species Rattus norvegicus (Rat)
Biological_Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using rat neutrophils is in a concentration range of 10-100 ng/ml.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence VVVASELRCQ CLTTLPRVDF KNIQSLTVTP PGPHCAQTEV IATLKDGHEV CLNPEAPLVQ RIVQKILNKG KAN
Research Area Immunology
Source E.coli
Gene Names Cxcl2
Expression Region 28-100aa
Tag Info Tag-Free
Mol. Weight 7.9 kDa
Protein Description Partial
PubMed ID 7665992; 7883948; 14624457; 1415488; 8043001; 8607872; 8471066
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Function Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.
Subcellular Location Secreted
Protein Families Intercrine alpha (chemokine CxC) family
Tissue Specificity At least expressed in the lung and trachea.
Database Links

KEGG: rno:114105

STRING: 10116.ENSRNOP00000003745

UniGene: Rn.10230

Pathway Chemokine signaling pathway
NF-kappa B signaling pathway
TNF signaling pathway
IL-17 signaling pathway
NOD-like receptor signaling pathway

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