CD40LG Antibody

Code CSB-PA004937ZA01MOW
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Product Details

Full Product Name Rabbit anti-Macaca mulatta (Rhesus macaque) CD40LG Polyclonal antibody
Uniprot No. P63304
Target Names CD40LG
Alternative Names CD40LG antibody; CD40L antibody; TNFSF5CD40 ligand antibody; CD40-L antibody; Tumor necrosis factor ligand superfamily member 5 antibody; CD antigen CD154) [Cleaved into: CD40 ligand antibody; membrane form; CD40 ligand antibody; soluble form antibody; sCD40L)] antibody
Raised in Rabbit
Species Reactivity Macaca mulatta
Immunogen Recombinant Macaca mulatta CD40LG protein
Immunogen Species Macaca mulatta (Rhesus macaque)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Target Background

Function
(From Uniprot)
Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.; Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Gene References into Functions
  1. Both two-trimer and four-trimer forms of macaque CD40L were active in B-cell proliferation assays using macaque and human cells. PMID: 16988005
Subcellular Location Cell membrane; Single-pass type II membrane protein. Cell surface.; [CD40 ligand, soluble form]: Secreted.
Protein Families Tumor necrosis factor family
Database Links

KEGG: mcc:574160

STRING: 9544.ENSMMUP00000018111

UniGene: Mmu.3581

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