CD40LG Antibody

Datasheet

Code	CSB-PA004937ZA01MOW
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Target Background

Product Details

Full Product Name

Rabbit anti-Macaca mulatta (Rhesus macaque) CD40LG Polyclonal antibody

Uniprot No.

P63304

Target Names

CD40LG

Alternative Names

CD40LG antibody; CD40L antibody; TNFSF5CD40 ligand antibody; CD40-L antibody; Tumor necrosis factor ligand superfamily member 5 antibody; CD antigen CD154) [Cleaved into: CD40 ligand antibody; membrane form; CD40 ligand antibody; soluble form antibody; sCD40L)] antibody

Raised in

Rabbit

Species Reactivity

Macaca mulatta

Immunogen

Recombinant Macaca mulatta CD40LG protein

Immunogen Species

Macaca mulatta (Rhesus macaque)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (12-14 weeks)

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Target Background

Function

Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.; Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.

Gene References into Functions

Both two-trimer and four-trimer forms of macaque CD40L were active in B-cell proliferation assays using macaque and human cells. PMID: 16988005

Subcellular Location

Cell membrane; Single-pass type II membrane protein. Cell surface.; [CD40 ligand, soluble form]: Secreted.

Protein Families

Tumor necrosis factor family

Database Links

KEGG: mcc:574160

STRING: 9544.ENSMMUP00000018111

UniGene: Mmu.3581

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Service

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Protein Service

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Related pathways

NF-kappa B signaling pathway T cell receptor signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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CD40LG Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background