DDB2 Antibody

Datasheet
Code CSB-PA652125XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q2YDS1
Delivery Make-to-order
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) DDB2 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2) ddb2 si:dkey-45f10.3
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Protocols ELISA Protocol
Gene Names ddb2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Required for DNA repair. Binds to ddb1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity).
Subcellular Location Nucleus
Protein Families WD repeat DDB2/WDR76 family
Database Links

UniGene: Dr.94422

Pathway p53 signaling pathway
DNA repair pathway
Ubiquitin mediated proteolysis

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