DRD2 Antibody

Code CSB-PA007179ZA01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) DRD2 Polyclonal antibody
Uniprot No. P14416
Target Names DRD2
Alternative Names DRD2; D(2 dopamine receptor; Dopamine D2 receptor
Raised in Rabbit
Species Reactivity Homo sapiens
Immunogen Recombinant Homo sapiens DRD2 protein
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugate
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Target Background

Function
(From Uniprot)
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.
Gene References into Functions
  1. In the overall participants, the DRD2 Taq 1A polymorphism itself was not related to IQ scores in children who had a high level of urine fluoride. In the CC/CT subgroup, urine fluoride levels and IQ scores in children were unrelated. Among the participants carrying the TT genotype, there was a strong and robust negative linear relationship between log-urine fluoride and IQ scores. PMID: 30205328
  2. this study demonstrated a protective role of D2R in neutrophil-endothelial cell adhesion induced by bradykinin, especially in cytokine-stimulated endothelial cells. PMID: 30148510
  3. DRD2 Ins/Ins (prevalence ratio (PR)=2.374, 95% confidence interval (CI): 1.105-5.100; P=0.027) and DRD3 Ser/Ser genotypes (PR=1.677, 95% CI 1.077-2.611; P=0.022) were independent and predictors of gastrointestinal symptoms associated with levodopa therapy. PMID: 27779245
  4. genetically determined differences in DAT1 and DRD2 expression modulate functional consequences of sleep deprivation. PMID: 28393838
  5. Study represents the first comprehensive investigation of the association between both striatal and extrastriatal D2/D3 receptor binding potential with executive function and verbal learning in medication-naive (5 drug-free) patients with schizophrenia; demonstrates that lower fallypride binding potential in patients with schizophrenia may be associated with better performance. PMID: 28576546
  6. these results suggest that among schizophrenia patients at the chronic stage, there is a relationship between Del carriers and high-dose pharmacotherapy. PMID: 28285026
  7. DRD2 C957T significantly affects performance on executive function related tasks in healthy individuals and shows for the first time that some of these effects may be mediated through the impact of childhood traumatic events. PMID: 28523234
  8. DRD2 gene moderates the relation between maternal history of maltreatment and infant emotion regulation. PMID: 28803562
  9. The TAQ1A1 allele of the DRD2 gene region contributes to shortened years of survival in alcohol dependent individuals, along with age and gender. PMID: 29236941
  10. Disruption of DRD2 promoted the proliferation of NSCLC cell lines by inhibiting the NF-kappaB signaling pathway and overexpression not only blocked lipopolysaccharide-induced cell proliferation and growth, but also inhibited the tumorigenesis in murine xenograft models. PMID: 30114693
  11. our results indicate a reduced natural-reward brain reactivity in smokers with the B1 allele of the DRD2 Taq1B polymorphism as evidenced with the approach-avoidance task. PMID: 28364268
  12. The G allele of DRD2 rs1800497 SNP was associated with a significant risk reduction of awake-sleep bruxism (p = 0.041). PMID: 28451935
  13. association to the purified GHSR:D2R heteromer triggers a different active conformation of Galphai that is linked to a higher rate of GTP binding and a faster dissociation from the heteromeric receptor. PMID: 29632174
  14. crystal structure of DRD2 in complex with the widely prescribed atypical antipsychotic drug risperidone PMID: 29466326
  15. analysis of molecular dynamics simulations with a cumulative length of ~77 mus of D2R and D3R wild-type and their E2.65A mutants bound to SB269652 PMID: 29337986
  16. In schizophrenia patients, presence of DRD2 Taq 1 D2D2 and 5-HT2A C516T CT genotypes in patients were more likely to be associated with non-response to risperidone. PMID: 28692863
  17. These results led us to hypothesize the existence of functional D2-sigma1R complexes on the rat striatal DA and glutamate nerve terminals and functional D2-sigma1R-DA transporter complexes on the striatal DA terminals. PMID: 28923416
  18. Current smokers showed lower ventral striatum levels of dopamine D2 receptors compared to non-smokers. PMID: 28643800
  19. The glioma-initiating cells self-renewal function regulated by PRRX1 is mediated by dopamine D2 receptor (DRD2). PRRX1 directly binds to the DRD2 promoter and transactivates its expression in glioma-initiating cells. PMID: 28486630
  20. ONC201 is a selective DRD2 antagonist that is well tolerated, achieves micromolar plasma concentrations, and is biologically active in advanced cancer patients when orally administered at 625 mg every 3 weeks PMID: 28331050
  21. DRD2 variation is associated with fiber tract integrity between basal ganglia and frontal cortices. PMID: 28392487
  22. The G allele of rs4654327 (OPRD1), DRD2 haplotype block CCGCCGTT (rs6277-rs1076560-rs2283265-rs2734833-rs2075652-rs1079596-rs4436578-rs11214607), and OPRD1 haplotypes TACG (rs6669447-rs2236857-rs508448-rs4654327), CG (rs508448-rs4654327), and TG (rs6669447-rs4654327) were significantly associated with heroin dependence phenotype. PMID: 28692418
  23. The constructed models using 38 D2R ligands (in the training set) were validated with 15 additional test set compounds. The resulting model correctly predicted the pIC50 values of an additional test set compounds as true unknowns PMID: 27367058
  24. case-control study by genotyping 7 SNPs of SLC6A2, SLC6A3 and DRD2 in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls PMID: 28454051
  25. Multimodal imaging results suggest that the distribution of D2/3 receptors in the posterior portion of the brain corresponds to the posterior default mode network, as well as to other functional networks to varying degrees. PMID: 28700819
  26. typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults PMID: 28089678
  27. No correlation was found between DRD2 polymorphisms and CAB responsiveness in patients with prolactinoma. More data are necessary in order to assess the influence of DRD2 genotyping on DA treatment response. PMID: 27848079
  28. DRD2 C947T (rs6277) may be associated with better performance on select cognitive domains independent of ANKK1 following Traumatic brain injury. PMID: 27826691
  29. The major allele A of rs2511521 located in DRD2 and the minor allele T of rs625413 located in TIRAP are significantly associated with increased risk of food addiction in overweight/obese subjects with low/zero food addiction symptoms. PMID: 28115213
  30. finding substantiates the conclusion that the detected community represents a more connected and informative cluster of genes for the DRD2 community, and therefore better elucidates the behavior of this module of strongly related DRD2 genes PMID: 29304112
  31. The neurotransmitter dopamine is linked to brain areas associated with reward, motivation, and attention, and common dopaminergic variants, DRD$ and DRD2 have been associated with attention difficulties. PMID: 26990357
  32. [(123)I]IBZM SPECT results show that striatal D2/3R availability increases after long-term bariatric-surgery induced weight loss, suggesting that reduced D2/3R availability in obesity is a reversible phenomenon. PMID: 27184782
  33. 3-chlorotyramine possesses a significant affinity by the D2 -DR. PMID: 27490860
  34. DRD2 C957T SNP influences flow proneness. PMID: 26954487
  35. Neurotransmission through D2-type receptors in the anterior cingulate and anterior insular cortices influences capacity of emotion processing in healthy people but that this association is absent in individuals with methamphetamine dependence. PMID: 26657175
  36. Suggest an effect of smoking on ventral striatal D2/3 dopamine receptors that may contribute to nicotine dependence. PMID: 27634830
  37. An association has been found between the DRD2/ANKK1 gene and alcohol use, and cognition. PMID: 27399274
  38. Data support the hypothesis of a negative influence of D2/3 receptor blockade on specific cognitive functions in schizophrenia. PMID: 26819282
  39. the D2 receptor system is associated with electrophysiological correlates of outcome evaluation processes PMID: 27021648
  40. DRD2/ANKK1-Taq1A gene is not a significant risk factor in the evolution of writer's cramp. PMID: 27696930
  41. DRD2/ANKK1 TaqIA allele status predicts striatal D2R specific binding as measured by D2R-selective [11C]NMB. PMID: 27241797
  42. DRD2 Taq1A may affect antipsychotic-related PRL levels in schizophrenic patients. PMID: 27333159
  43. Involvement of DRD2 not only in schizophrenia but also in elevated levels of blood glucose. PMID: 27254804
  44. The most characteristic signaling pathways for B2R and D2R, dependent on intracellular Ca(2+) and cAMP concentration, respectively, were analyzed in cells presenting similar endogenous expression of B2R and D2R.The evidence of B2R-D2R dimerization may open new perspectives in the modulation of diverse cellular functions which depend on their activation. PMID: 28757212
  45. In acute schizophrenia patients, the mRNA expression levels of DRD2 and PI3KCB were significantly lower than those in the healthy controls, while the AKT1 mRNA levels were significantly higher than those in the healthy controls. PMID: 27449010
  46. Our data support the critical role of C957T in striatal D2/3 receptor availability. This work has implications for a number of psychiatric conditions in which dopamine signaling and variation in C957T status have been implicated, including schizophrenia and substance use disorders. PMID: 28398340
  47. Further analysis revealed that the adenosine agonist 5'-N-ethylcarboxamidoadenosine, a previously identified promoter of b cell proliferation, acted with DPD to increase the number of b cells. In humans, dopamine also modulates b cell mass through DRD2 and exerts an inhibitory effect on adenosine signaling. PMID: 27373926
  48. Greater predicted DRD2 pathway prefrontal co-expression was associated with greater prefrontal activity and longer working memory reaction times in schizophrenic patients. PMID: 28094815
  49. Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of D2R through GRK2. Knockdown of FLNA or coexpression of active RalA interfered with the recycling of the internalized D2R and resulted in the development of receptor tolerance. Active RalA was found to interact with GRK2 to sequester it from D2R. PMID: 27188791
  50. Using the human glycosylated native conformational D2R, study shows the importance of D2R extracellular N-terminus in regulating receptor availability at the cell surface, human anti-D2R antibody binding, and potential pathogenic mechanisms of these antibodies. PMID: 27908295

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Subcellular Location Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein Families G-protein coupled receptor 1 family
Tissue Specificity [Isoform 1]: Expressed in the anterior pituitary gland.; [Isoform 2]: Expressed in the anterior pituitary gland.
Database Links

HGNC: 3023

OMIM: 103780

KEGG: hsa:1813

STRING: 9606.ENSP00000354859

UniGene: Hs.73893

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