Fadd Antibody

Code CSB-PA893221XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Fadd Polyclonal antibody
Uniprot No.
Target Names
Fadd
Alternative Names
Fadd antibody; BG4 antibody; CG12297Fas-associated death domain protein antibody; Death domain-containing adapter protein BG4 antibody; FAS-associating death domain-containing protein antibody; dFADD antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Fadd protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.
Gene References into Functions
  1. demonstrate that dFADD is a novel component of the immune deficiency pathway; double-stranded RNA expression reduces the induction of antibacterial peptide-encoding genes after infection and renders the fly susceptible to Gram-negative bacterial infection PMID: 12123572
  2. dFADD acts downstream of IMD protein in the pathway that controls inducibility of the antibacterial peptide genes PMID: 12433364
Subcellular Location
Cytoplasm.
Database Links

KEGG: dme:Dmel_CG12297

STRING: 7227.FBpp0083574

UniGene: Dm.1273

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