Gnai2 Antibody

1. paraventricular nucleus Galphai(2) protein pathways play an endogenous role in maintaining fluid and electrolyte balance by controlling the influence the sympathetic nervous system has on the renal handling of sodium PMID: 22459149
2. endoplasmic reticulum-resident G(i2) protein is an important negative regulator of vesicular transport at the early stage of vesicle formation before coat protein assembly PMID: 21480366
3. involvement of Gi2 in activation of extracellular signal-regulated kinases in hepatocytes PMID: 11495629
4. Gi2 has a role in regulating mitogenic activity in the neural progenitor cells of developing brain PMID: 15272018
5. Alternatively spliced variant G alpha i2 is widely expressed in rat brain regions known to play a crucial role in brain function. PMID: 15312896
6. heterologous desensitization in INS-1 cells may be mediated by Galphai2 changes but depend on the cAMP/PKA signalling pathway probably distant form the Galphai2 protein PMID: 15376236
7. This novel alternatively spliced isoform of Galphai2 putatively encodes a truncated protein that could serve unique roles in the physiology of the vestibular neuroepithelium. PMID: 15950765
8. Galphai2 has an essential regulatory role in ciliary function and cerebral spinal fluid homeostasis. PMID: 17430589
9. results indicate that the upregulation of Gi2 in ischemic myocardium appears to be protective in inducing cell survival pathways to prevent myocyte death in response to ischemia/reperfusion injury PMID: 18316484
10. Highest protein level was observed at the age of P0. There was also a trend of decline in the sGalphai2 protein from P0 to P90 in brain PMID: 18472243
11. change of G[alpha]i2, G[alpha]q mRNA, and their proteins in severe acute pancreatitis PMID: 18665079
12. role of Galpha(i2) in development of insulin resistance PMID: 18981538
13. Overexpression of Galpha(i2), PDE2a, and RGS2 down-regulates the beta-adrenergic signaling pathway, thus contributing to the pathogenesis of cirrhotic cardiomyopathy. PMID: 19003918

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KEGG: rno:81664

STRING: 10116.ENSRNOP00000022550

UniGene: Rn.3036