IKKA Antibody

Code CSB-PA676836XA01DIL
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Product Details

Full Product Name Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) chuk Polyclonal antibody
Uniprot No. Q4G3H4
Target Names chuk
Alternative Names chuk antibody; ikk1 antibody; zgc:56539 antibody; Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody; I kappa-B kinase alpha antibody; IKK-A antibody; IKK-alpha antibody; IkBKA antibody; IkappaB kinase antibody; EC 2.7.11.10 antibody; Conserved helix-loop-helix ubiquitous kinase antibody; I-kappa-B kinase 1 antibody; IKK1 antibody; Nuclear factor NF-kappa-B inhibitor kinase alpha antibody; NFKBIKA antibody
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) IKKA protein
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Made-to-order

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Target Data

Function Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
Gene References into Functions
  1. These findings reveal a molecular mechanism regulating migration and invasion of epithelial cells and establish a key direct link between IKKbeta and cell motility controlled by Rap-integrin signaling. PMID: 24290981
  2. poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis PMID: 20692251
  3. Ikk1 negatively regulates NF-kappaB by sequestering NEMO from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB. PMID: 16051172
Subcellular Location Cytoplasm, Nucleus
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily
Database Links

KEGG: dre:393287

STRING: 7955.ENSDARP00000013115

UniGene: Dr.14012

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