Mtor Antibody

Datasheet

Code	CSB-PA131316XA01DLU
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Mtor Polyclonal antibody

Uniprot No.

A1Z8P9

Target Names

Mtor

Alternative Names

Mtor antibody; Bx34 antibody; l(2)k03905 antibody; CG8274 antibody; Nucleoprotein TPR antibody; Megator antibody; Nuclear envelope antigen Bx34 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Mtor protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome. Associates with extended chromosomal regions that alternate between domains of high density binding with those of low occupancy. Preferentially binds to NARs of the male X chromosome. In males, together with Nup153, required for the localization of the male-specific lethal (MSL) histone acetyltransferase complex to the X chromosome and therefore for the transcription of dosage compensation genes. During mitosis forms a gel-like spindle matrix complex together with Skeletor, Chro, east, and Asator embedding the microtubule spindle apparatus. During interphase localizes Mad1 to the nuclear pore complex and thereby might act as a scaffold to assemble the Mad1-C-Mad2 complex, an heterotetramer that catalyzes the structural conversion of open-Mad2 (O-Mad2) into closed-Mad2 (C-Mad2) which is essential for spindle-assembly checkpoint (SAC). During the metaphase-anaphase transition and before chromosome congression, is phosphorylated by Msp-1; this modification releases Mad1 from the nuclear pore complex and thereby promotes assembly of SAC ensuring a timely and effective recruitment of spindle checkpoint proteins like Mad1, Mad2 and Mps1 to unattached kinetochores (KT). In testes, has a role in stem cell asymmetric division and maintenance via regulation of mitotic spindle assembly checkpoint (SAC) complex.

Gene References into Functions

Data show that the spindle matrix complex, including Chromator/Chriz (Chro), Megator (Mtor), and enhanced adult sensory threshold (East), has a novel nuclear function in reactivation of neural stem cells (NSCs). PMID: 28744001
Mtor is required for the correct centrosome orientation, mitotic spindle formation, and chromosome segregation. PMID: 26714316
WAC promotes the interaction between TTT and Pontin/Reptin in an energy-dependent manner, thereby promoting mTORC1 activity by facilitating mTORC1 dimerization and mTORC1-Rag interaction PMID: 26812014
Data show that the spindle matrix protein Megator requires its coiled-coil amino-terminal domain for spindle matrix localization. PMID: 22855526
Reduced TOR activity promotes grk translation independent of the canonical Vasa-RNA helicase and cap-dependent mechanism. PMID: 22328499
Megator is an essential coiled-coil protein that localizes to the putative spindle matrix during mitosis in Drosophila PMID: 15356261
Megator and EAST interact to form a nuclear endoskeleton and as well are important components of the putative spindle matrix complex during mitosis PMID: 15962301
We propose that Mtor/Tpr functions as a spatial regulator of the SAC, which ensures the efficient recruitment of Mad2 to unattached KTs at the onset of mitosis and proper spindle maturation. PMID: 19273613

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Subcellular Location

Nucleus. Nucleus matrix. Nucleus lamina. Nucleus envelope. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody.

Protein Families

TPR family

Tissue Specificity

Expressed in salivary glands, fat body, tracheal tube, esophageal tube and anterior ejaculatory duct (at protein level).

Database Links

KEGG: dme:Dmel_CG8274

STRING: 7227.FBpp0304737

UniGene: Dm.4634

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Transmembrane Protein Questionnaire with Gifts

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Related pathways

ErbB signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Autophagy Cellular senescence Th17 cell differentiation Adipocytokine signaling pathway AMPK signaling Apelin signaling pathway Insulin signaling pathway Oxidative Phosphorylation Phospholipase D signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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