Human Vascular cell adhesion molecule 1,VCAM-1 ELISA kit

Instructions
Code CSB-E04753h
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name vascular cell adhesion molecule 1
Alternative Names CD106 ELISA Kit; CD106 Antigen ELISA Kit; INCAM 100 ELISA Kit; INCAM-100 ELISA Kit; L1CAM ELISA Kit; MGC99561 ELISA Kit; V-CAM 1 ELISA Kit; Vascular Cell Adhesion Molecule 1 ELISA Kit; Vascular cell adhesion protein 1 ELISA Kit; VCAM 1 ELISA Kit; VCAM-1 ELISA Kit; VCAM1 ELISA Kit; VCAM1_HUMAN ELISA Kit
Abbreviation VCAM1
Uniprot No. P19320
Species Homo sapiens (Human)
Sample Types serum, plasma, tissue homogenates
Detection Range 1.563 ng/mL-100 ng/mL
Sensitivity 0.611 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cardiovascular
Assay Principle quantitative
Measurement Sandwich
Precision

 

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays):CV%<10%

Three samples of known concentration were tested in twenty assays to assess.

 

Linearity

 

To assess the linearity of the assay, samples were spiked with high concentrations of human VCAM-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

Typical Data

 

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

 

Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Data

Function Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Gene References into Functions
  1. High VCAM1 expression is associated with Cardiovascular Disease. PMID: 28496046
  2. not a specific screening marker for pulmonary arterial hypertension in systemic sclerosis PMID: 29687288
  3. We observed an increase of VCAM-1 urine levels in diabetic nephropathy-basal patients compared to diabetic controls and an increase of urinary neprilysin in DN-treated patients with persistent albuminuria PMID: 29854824
  4. Urinary angiostatin and VCAM-1 are predictive of specific histological changes in concurrent lupus nephritis renal biopsies. PMID: 29076253
  5. In summary, it could be concluded that the expression of gene VCAM-1 was down regulated by taurocholic acid through miR-590-3p and that gene VCAM-1 could participate in the regulation of cell growth, cell proliferation and cell apoptosis PMID: 28851649
  6. VCAM-1 expression is upregulated by CD34+/CD133+-stem cells derived from septic patients PMID: 29601599
  7. Circulating soluble vascular cell adhesion molecule (VCAM-1) level was a useful diagnostic parameter for understanding the difference between coronary artery disease (CAD) and cardiac syndrome X (CSX). PMID: 28675064
  8. findings indicate a novel role for JAK2-V617F in activation of beta1 integrins and enhanced adhesion of granulocytes and 32D myeloid progenitors to VCAM1-coated surfaces PMID: 28096537
  9. High VCAM1 expression is associated with Cardiovascular Disease Risk. PMID: 28202840
  10. VCAM-1 levels are elevated in serum of cystic fibrosis patients. PMID: 28646244
  11. VCAM-1 levels are able to accurately predict significant fibrosis in non-alcoholic fatty liver disease patients PMID: 28461687
  12. These results revealed the effect of CD106 and NF-kappaB in bone marrow failure of Acquired aplastic anemia. PMID: 28764810
  13. Overexpression of LINC00341 suppresses the expression of vascular cell adhesion molecule 1 (VCAM1) and the adhesion of monocytes induced by atheroprone flow and tumor necrosis factor-alpha. PMID: 28500253
  14. Increased expression of PECAM-1, ICAM-3, and VCAM-1 in colonic biopsies from patients with inflammatory bowel disease (IBD) in clinical remission is associated with subsequent flares; this suggests that increases in the expression of these proteins may be early events that lead to flares in patients with IBD PMID: 27552332
  15. Association with the efficiency of hematopoietic stem cells (HSC) mobilization to PB were found in the SNPs of the DGKB gene involved in cell transport and SDF-1-induced migration ability and of the VCAM1 gene which is essential for HSC homing, suggesting that SNPs involved in cell migration ability might be partly involved in HSC PMID: 27839966
  16. sVCAM-1 reflects xerostomia in primary Sjogren's syndrome. sICAM-1 and sE-selectin may be additional parameters of secondary Sjogren's syndrome activity. PMID: 29068581
  17. Augmented expression of endothelial adhesion molecules ICAM1/VCAM1 is involved in the pathophysiology of patients with antiphospholipid syndrome. PMID: 29096830
  18. VCAM-1 knockdown reduced TNFalpha-induced HUVEC migration and tube formation. PMID: 28209985
  19. High levels of serum ICAM-1 was associated with the development of multiple organ failure . High levels of VCAM-1 was associated with both multiple organ failure and in-hospital mortality. PMID: 27701021
  20. VCAM1 protein expression increased in cartilage tissue from spinal tuberculosis patients. PMID: 28829887
  21. This study provided direct evidence that increasing extracellular Ca(2+) enhanced TNF-alpha-induced VCAM-1 activation and monocytes adhesion. Moreover, we identified a novel TRPC1/ERK1/2/NFkappaB signaling pathway mediating VCAM-1 activation and monocyte adhesion in this pathological process. PMID: 28583863
  22. Findings suggest that sVCAM-1 is related to affective temperaments, and it is a trait marker for liability to mood disorders. This relationship between alterations in cellular adhesion and affective temperament may be important for vulnerability to affective disorders. PMID: 27693464
  23. patients with newly-diagnosed MM have increased serum levels of VCAM-1 and ICAM-1 that correlate with advanced disease features. VCAM-1 is also independently correlated with survival, suggesting an important role in the biology of the disease and supporting its targeting with novel anti-myeloma drugs. PMID: 27232930
  24. VCAM-1 was statistically elevated in major depressive disorder. PMID: 27598970
  25. Data show that podoplanin (PDPN), CD106 (VCAM-1) and CD248 protein were increased in diseased compared to healthy tendon cells. PMID: 28122639
  26. Peptide nanoparticles targeting VCAM-1 are suggested as a theranostic carrier for drug delivery to inflamed endothelium. PMID: 27105996
  27. IRF-5 targeted the expression of vascular cell adhesion molecule 1 (VCAM-1) at the transcriptional level by binding to its promoter. PMID: 28818665
  28. In patients with optic neuritis that developed into multiple sclerosis, there was a decrease in serum VCAM-1. PMID: 27806869
  29. There was a negative correlation of miR-126 with the PCI-induced markers of inflammation such as hs-CRP and VCAM-1 PMID: 27900989
  30. this study shows that quercetin reduces the expression of VCAM-1 in oxidized LDL cholesterol-induced endothelial cells PMID: 27585526
  31. Gastrin-releasing peptide (GRP) increased the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) by activating nuclear factor-kappaB (NF-kappaB) in endothelial cells. PMID: 28093230
  32. Mesothelium VCAM-1 expression is negatively associated with progression-free and overall survival in EOC. This is especially compelling in light of previous data suggesting that persistent VCAM-1 expression during treatment is an indicator of platinum resistance. PMID: 28263384
  33. The results of this study suggest that VCAM-1 gene variants may be related to obesity and inflammatory markers in the Korean population PMID: 27853845
  34. Panax notoginseng saponins and Ginsenoside protect aorta form atherosclerosis via Rb1 via activation of Nrf2 and suppression of p38 - VCAM-1 signal pathway. PMID: 27620662
  35. Our results suggest that an impairment in adhesion exists in vitiligo skin, which is supported by the diminished immunohistochemical expression of laminin, beta1 integrin, ICAM-1 and VCAM-1. PMID: 28214208
  36. Th1-induced CD106 expression mediates leukocytes adhesion on synovial fibroblasts from juvenile idiopathic arthritis patients via TNF-alpha. PMID: 27123929
  37. Although the expression of VCAM-1 was higher in adult T-cell leukemia/lymphoma patients individuals, there was no significant difference between the studied groups. PMID: 28110427
  38. Activin A and preeclamptic serum upregulate ET-1, ICAM-1, and VCAM-1 in human umbilical vein endothelial cells, consistent with activin A contributing to the pathophysiology of preeclampsia. PMID: 27155341
  39. Statistically significant associations were identified between the chronic periodontal patients and the controls in the gene polymorphisms of rs5498 ICAM-1 (P=0.007) and rs1041163 VCAM-1 (P=0.029). The distribution of rs5498 (P=0.029) and rs1041163 (P=0.049) differed significantly across the mild, moderate, and severe groups of periodontitis. PMID: 27391418
  40. VCAM-1 had a synergistic effect with coronary artery disease on the BDNF PMID: 28131673
  41. findings suggest that the increased levels of IL-17,Hcy and sVCAM contributes contributes to the vascular inflammation and activation presented by sickle cell anemia patients PMID: 26334689
  42. VCAM-1 plays an important role in the development and generation of gestational hypertension. PMID: 27706617
  43. gLDL stimulate the expression of cellular VCAM-1, the secretion of soluble VCAM-1, and the adhesion of monocytes through mechanisms involving p38 MAP kinase and NF-kB signalling pathways activated by RAGE, ERS and oxidative stress, thus contributing to diabetic atherosclerosis. PMID: 27206739
  44. High VCAM1 expression is associated with non-insulin resistant women with polycystic ovary syndrome. PMID: 27245110
  45. Denbinobin inhibited IL-1beta-induced ICAM-1/VCAM-1 expression and monocyte adhesion to osteoarthritis fibroblast-like synoviocytes via mirn146-a PMID: 25052989
  46. Theobroma cacao extract prohibits the increase in IL-6 and sVCAM-1 in endothelial cells induced by plasma from preeclamptic patients. PMID: 26955771
  47. BD patients have a lower expression of ICAM-1, VCAM-1, and E-selectin in their tumor tissues. BD-HDL facilitates the adhesion of tumor cells to vascular endothelium by upregulating the expression of ICAM-1 and VCAM-1, thereby promoting the initial progression of breast cancer metastasis PMID: 26872904
  48. Clopidogrel diminishes TNFalpha-stimulated VCAM-1 expression at least in part via HO-1 induction and CaMKKbeta/AMPK/Nrf2 pathway in endothelial cells. PMID: 26824050
  49. Results show that VCAM1 expression is regulated by TSPO to activate endothelial cells. PMID: 26608360
  50. Human placental, chorionic villi-derived mesenchymal stem cells expressing VCAM-1 promote angiogenesis in a mouse ischemia model. PMID: 27044487

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Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
Database Links

HGNC: 12663

OMIM: 192225

KEGG: hsa:7412

STRING: 9606.ENSP00000294728

UniGene: Hs.109225

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