Recombinant Human Vascular cell adhesion protein 1(VCAM1),partial

Code CSB-YP025809HU
Size US$1298
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names VCAM1
Uniprot No. P19320
Research Area Cell Adhesion
Alternative Names CD106; CD106 Antigen; INCAM 100; INCAM-100; L1CAM; MGC99561; V-CAM 1; Vascular Cell Adhesion Molecule 1; Vascular cell adhesion protein 1; VCAM 1; VCAM-1; VCAM1; VCAM1_HUMAN
Species Homo sapiens (Human)
Source Yeast
Expression Region 25-698aa
Target Protein Sequence FKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPE
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 76.2kDa
Protein Length Extracellular Domain
Tag Info N-terminal 6xHis-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Gene References into Functions
  1. High VCAM1 expression is associated with Cardiovascular Disease. PMID: 28496046
  2. not a specific screening marker for pulmonary arterial hypertension in systemic sclerosis PMID: 29687288
  3. We observed an increase of VCAM-1 urine levels in diabetic nephropathy-basal patients compared to diabetic controls and an increase of urinary neprilysin in DN-treated patients with persistent albuminuria PMID: 29854824
  4. Urinary angiostatin and VCAM-1 are predictive of specific histological changes in concurrent lupus nephritis renal biopsies. PMID: 29076253
  5. In summary, it could be concluded that the expression of gene VCAM-1 was down regulated by taurocholic acid through miR-590-3p and that gene VCAM-1 could participate in the regulation of cell growth, cell proliferation and cell apoptosis PMID: 28851649
  6. VCAM-1 expression is upregulated by CD34+/CD133+-stem cells derived from septic patients PMID: 29601599
  7. Circulating soluble vascular cell adhesion molecule (VCAM-1) level was a useful diagnostic parameter for understanding the difference between coronary artery disease (CAD) and cardiac syndrome X (CSX). PMID: 28675064
  8. findings indicate a novel role for JAK2-V617F in activation of beta1 integrins and enhanced adhesion of granulocytes and 32D myeloid progenitors to VCAM1-coated surfaces PMID: 28096537
  9. High VCAM1 expression is associated with Cardiovascular Disease Risk. PMID: 28202840
  10. VCAM-1 levels are elevated in serum of cystic fibrosis patients. PMID: 28646244
  11. VCAM-1 levels are able to accurately predict significant fibrosis in non-alcoholic fatty liver disease patients PMID: 28461687
  12. These results revealed the effect of CD106 and NF-kappaB in bone marrow failure of Acquired aplastic anemia. PMID: 28764810
  13. Overexpression of LINC00341 suppresses the expression of vascular cell adhesion molecule 1 (VCAM1) and the adhesion of monocytes induced by atheroprone flow and tumor necrosis factor-alpha. PMID: 28500253
  14. Increased expression of PECAM-1, ICAM-3, and VCAM-1 in colonic biopsies from patients with inflammatory bowel disease (IBD) in clinical remission is associated with subsequent flares; this suggests that increases in the expression of these proteins may be early events that lead to flares in patients with IBD PMID: 27552332
  15. Association with the efficiency of hematopoietic stem cells (HSC) mobilization to PB were found in the SNPs of the DGKB gene involved in cell transport and SDF-1-induced migration ability and of the VCAM1 gene which is essential for HSC homing, suggesting that SNPs involved in cell migration ability might be partly involved in HSC PMID: 27839966
  16. sVCAM-1 reflects xerostomia in primary Sjogren's syndrome. sICAM-1 and sE-selectin may be additional parameters of secondary Sjogren's syndrome activity. PMID: 29068581
  17. Augmented expression of endothelial adhesion molecules ICAM1/VCAM1 is involved in the pathophysiology of patients with antiphospholipid syndrome. PMID: 29096830
  18. VCAM-1 knockdown reduced TNFalpha-induced HUVEC migration and tube formation. PMID: 28209985
  19. High levels of serum ICAM-1 was associated with the development of multiple organ failure . High levels of VCAM-1 was associated with both multiple organ failure and in-hospital mortality. PMID: 27701021
  20. VCAM1 protein expression increased in cartilage tissue from spinal tuberculosis patients. PMID: 28829887
  21. This study provided direct evidence that increasing extracellular Ca(2+) enhanced TNF-alpha-induced VCAM-1 activation and monocytes adhesion. Moreover, we identified a novel TRPC1/ERK1/2/NFkappaB signaling pathway mediating VCAM-1 activation and monocyte adhesion in this pathological process. PMID: 28583863
  22. Findings suggest that sVCAM-1 is related to affective temperaments, and it is a trait marker for liability to mood disorders. This relationship between alterations in cellular adhesion and affective temperament may be important for vulnerability to affective disorders. PMID: 27693464
  23. patients with newly-diagnosed MM have increased serum levels of VCAM-1 and ICAM-1 that correlate with advanced disease features. VCAM-1 is also independently correlated with survival, suggesting an important role in the biology of the disease and supporting its targeting with novel anti-myeloma drugs. PMID: 27232930
  24. VCAM-1 was statistically elevated in major depressive disorder. PMID: 27598970
  25. Data show that podoplanin (PDPN), CD106 (VCAM-1) and CD248 protein were increased in diseased compared to healthy tendon cells. PMID: 28122639
  26. Peptide nanoparticles targeting VCAM-1 are suggested as a theranostic carrier for drug delivery to inflamed endothelium. PMID: 27105996
  27. IRF-5 targeted the expression of vascular cell adhesion molecule 1 (VCAM-1) at the transcriptional level by binding to its promoter. PMID: 28818665
  28. In patients with optic neuritis that developed into multiple sclerosis, there was a decrease in serum VCAM-1. PMID: 27806869
  29. There was a negative correlation of miR-126 with the PCI-induced markers of inflammation such as hs-CRP and VCAM-1 PMID: 27900989
  30. this study shows that quercetin reduces the expression of VCAM-1 in oxidized LDL cholesterol-induced endothelial cells PMID: 27585526
  31. Gastrin-releasing peptide (GRP) increased the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) by activating nuclear factor-kappaB (NF-kappaB) in endothelial cells. PMID: 28093230
  32. Mesothelium VCAM-1 expression is negatively associated with progression-free and overall survival in EOC. This is especially compelling in light of previous data suggesting that persistent VCAM-1 expression during treatment is an indicator of platinum resistance. PMID: 28263384
  33. The results of this study suggest that VCAM-1 gene variants may be related to obesity and inflammatory markers in the Korean population PMID: 27853845
  34. Panax notoginseng saponins and Ginsenoside protect aorta form atherosclerosis via Rb1 via activation of Nrf2 and suppression of p38 - VCAM-1 signal pathway. PMID: 27620662
  35. Our results suggest that an impairment in adhesion exists in vitiligo skin, which is supported by the diminished immunohistochemical expression of laminin, beta1 integrin, ICAM-1 and VCAM-1. PMID: 28214208
  36. Th1-induced CD106 expression mediates leukocytes adhesion on synovial fibroblasts from juvenile idiopathic arthritis patients via TNF-alpha. PMID: 27123929
  37. Although the expression of VCAM-1 was higher in adult T-cell leukemia/lymphoma patients individuals, there was no significant difference between the studied groups. PMID: 28110427
  38. Activin A and preeclamptic serum upregulate ET-1, ICAM-1, and VCAM-1 in human umbilical vein endothelial cells, consistent with activin A contributing to the pathophysiology of preeclampsia. PMID: 27155341
  39. Statistically significant associations were identified between the chronic periodontal patients and the controls in the gene polymorphisms of rs5498 ICAM-1 (P=0.007) and rs1041163 VCAM-1 (P=0.029). The distribution of rs5498 (P=0.029) and rs1041163 (P=0.049) differed significantly across the mild, moderate, and severe groups of periodontitis. PMID: 27391418
  40. VCAM-1 had a synergistic effect with coronary artery disease on the BDNF PMID: 28131673
  41. findings suggest that the increased levels of IL-17,Hcy and sVCAM contributes contributes to the vascular inflammation and activation presented by sickle cell anemia patients PMID: 26334689
  42. VCAM-1 plays an important role in the development and generation of gestational hypertension. PMID: 27706617
  43. gLDL stimulate the expression of cellular VCAM-1, the secretion of soluble VCAM-1, and the adhesion of monocytes through mechanisms involving p38 MAP kinase and NF-kB signalling pathways activated by RAGE, ERS and oxidative stress, thus contributing to diabetic atherosclerosis. PMID: 27206739
  44. High VCAM1 expression is associated with non-insulin resistant women with polycystic ovary syndrome. PMID: 27245110
  45. Denbinobin inhibited IL-1beta-induced ICAM-1/VCAM-1 expression and monocyte adhesion to osteoarthritis fibroblast-like synoviocytes via mirn146-a PMID: 25052989
  46. Theobroma cacao extract prohibits the increase in IL-6 and sVCAM-1 in endothelial cells induced by plasma from preeclamptic patients. PMID: 26955771
  47. BD patients have a lower expression of ICAM-1, VCAM-1, and E-selectin in their tumor tissues. BD-HDL facilitates the adhesion of tumor cells to vascular endothelium by upregulating the expression of ICAM-1 and VCAM-1, thereby promoting the initial progression of breast cancer metastasis PMID: 26872904
  48. Clopidogrel diminishes TNFalpha-stimulated VCAM-1 expression at least in part via HO-1 induction and CaMKKbeta/AMPK/Nrf2 pathway in endothelial cells. PMID: 26824050
  49. Results show that VCAM1 expression is regulated by TSPO to activate endothelial cells. PMID: 26608360
  50. Human placental, chorionic villi-derived mesenchymal stem cells expressing VCAM-1 promote angiogenesis in a mouse ischemia model. PMID: 27044487
  51. This study showed that sVCAM-1 levels were decreased in early and late stages of schizophrenia. PMID: 26679764
  52. Soluble VCAM1 levels correlated with clinical response in systemic lupus erythematosus patients. PMID: 26746423
  53. These metastatic tumors revealed no detectable expression of CK8/18, E-cadherin, VCAM-1, and ICAM-1 PMID: 26847082
  54. ICAM-1, VCAM-1 and CD34 are useful biomarkers in evaluation of vascular and inflammatory lesions such as gingival pyogenic granuloma and the results indicate the role of these biomarkers in pathogenesis of oral pyogenic granuloma. PMID: 26625754
  55. Among Alzheimer disease patients, VCAM-1 levels significantly reflected the severity of dementia and showed an association with macro- and micro- white matter changes, independent of age and cortical volume. PMID: 26289958
  56. VCAM-1 is a TGF-beta1 responsive mediator that partakes in fibroblast proliferation in subjects with idiopathic pulmonary fibrosis. PMID: 26386411
  57. sVCAM-1 concentrations were significantly higher in the bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome compared to healthy controls, and tended to be higher in moderate/severe ARDS compared to mild ARDS. PMID: 26919714
  58. Identify the selectins ICAM-1 and VCAM-1 as strong and independent predictors of all-cause and cardiovascular mortality in patients with stable carotid atherosclerosis. PMID: 25994120
  59. VCAM-1 and ICAM-1 have opposite roles in complications of diabetes PMID: 25990052
  60. neutrophils are reliant on endothelial activation for adhesion, initially via E-selectin and subsequently, by integrin-mediated binding to ICAM-1 and VCAM-1, combined with CXCL8-dependent chemotaxis. PMID: 26216937
  61. these results indicate that in HCFs, activation of NF-kappaB by c-Src-mediated transactivation of EGFR/PI3K/Akt cascade is required for TNF-alpha-induced VCAM-1 expression. PMID: 26173590
  62. Tumor-produced SPARC and VCAM1 are regulators of cancer extravasation. PMID: 25925867
  63. Data suggest plasma levels of VCAM1 (but not ICAM1) are up-regulated in Asian subjects (Singapore) with type 2 diabetes mellitus complicated by chronic renal insufficiency; plasma levels of ICAM1 appear to be up-regulated in systemic inflammation. PMID: 25857767
  64. Heterogeneity was found in the endothelial cells: their shape, the expression of adhesion molecules(ICAM-1, VCAM-1, and PECAM ), and the adhesion of lymphocytes and monocytes to them changed during the progression of the atherosclerotic process. PMID: 26841644
  65. Effect of PKC-beta Signaling Pathway on Expression of MCP-1 and VCAM-1 in Different Cell Models in Response to Advanced Glycation End Products PMID: 26008233
  66. an 'in solution' steady state organic fluorophore based quantitative fluorescence resonance energy transfer (FRET) assay to quantify VLA-4/VCAM-1 interaction. PMID: 25793408
  67. VCAM1 is involved in gastric tumor cell invasion by mediating nerve-tumor interaction. PMID: 26108418
  68. sVCAM-1 concentrations are useful indicators of the presence of atherosclerosis in coronary arteries, but not its advancement. PMID: 25638707
  69. VCAM-1 expression on endothelial cells and formation of endothelial cell microparticles at the site of coronary plaque is positively correlated with the extent of vascular inflammation in patients with myocardial infarction. PMID: 25413339
  70. Blood VCAM1 was higher in pregnant women with preeclampsia, and non-pregnant women with a history of preeclampsia than women without preeclampsia or a history of preeclampsia. PMID: 26116870
  71. Level of circulating VCAM-1 cannot be used as marker of aortic stiffness in patients. PMID: 25784313
  72. Our findings showed that rs3783605 polymorphism may play a role in VCAM-1 gene expression PMID: 25780884
  73. ATF-2 was also required for other endothelial cell outputs, such as cell migration and tubulogenesis. In contrast, VCAM-1 was essential only for promoting endothelial-leukocyte interactions. PMID: 24966171
  74. ET-1 promotes occurrence and amplification of pathology-related airway inflammation via enhancing VCAM-1 expression. PMID: 26071554
  75. VCAM-1 may play a role in the pathogenesis of endometriosis. PMID: 25473757
  76. This study suggests that osteoblast-derived WISP-1 promotes migration and VCAM-1 expression in human prostate cancer cells by down-regulating miR-126 expression PMID: 25277191
  77. This study found no association between VCAM1 c.1238G>C and stroke PMID: 25175566
  78. Overall survival was significantly shorter in patients with high LVD and ICAM-1 or VCAM-1 expression in lymphatic vessels. PMID: 25450269
  79. There was a significant increase in plasma AM, VCAM-1, and ICAM-1, while a significant decrease in plasma basic-Fibroblast growth factor (b-FGF) in diabetic patients with peripheral vascular disease (p < 0.05). PMID: 25287126
  80. Data show that family with sequence similarity 5 member C protein FAM5C-positive endothelium expressed intercellular adhesion molecule-1 (ICAM-1) or vascular cell adhesion molecule-1 (VCAM-1). PMID: 25251368
  81. Adhesion of prostate cancer cells to vascular endothelial cells is enhanced through increasing VCAM-1 expression. PMID: 25683512
  82. Urinary VCAM-1 was found to be elevated in lupus nephritis patients and was a reliable indicator of renal pathology activity. PMID: 22788914
  83. This suggests that increased plasma VCAM-1 concentration may be useful in identifying who are at risk of hospital mortality among severely septic patients requiring mechanical ventilation PMID: 24998754
  84. Results show that VCAM-1 is a keyplayer with multiple functionalities for directing the metastatic spread of tumors, for the formation of metastatic niche and supporting the angiogenetic process. [review] PMID: 24771582
  85. Plasma soluble VCAM and ICAM in coronary ectasia are elevated in comparison to atherosclerotic coronary artery disease. PMID: 25034460
  86. Combinatorial expression of NKX2-5, SIRPA, VCAM1 and CD34 can be used to define discrete stages of cardiovascular cell lineage differentiation. PMID: 24968096
  87. mRNA were analyzed by RT-PCR and agarose gel. With beta-amyrin, the 50% RAW conditioned media-induced E-selectin, sICAM-1, and sVCAM-1 levels as well as ET-1 gene expression were all suppressed. PMID: 25045892
  88. Time to recurrence was shorter for patients who had a variant allele in vascular cellular adhesion molecule 1 (VCAM1) and were treated with immunotherapy. PMID: 24666523
  89. Inhibition of ER stress with a chemical chaperone 4-phenylbutyric acid decreased TNFalpha-induced VCAM-1 expression. PMID: 24205197
  90. Data show that VCAM-1 (CD106) physically associates with CD44 antigen. PMID: 24583847
  91. Jurkat cells can over-express MIP-1alpha, which up-regulates the expression of endothelial adhesion molecules VCAM-1 and ICAM-1 to promote Jurkat cells' transendothelial migration PMID: 25245399
  92. CORM-2, which liberates CO to elicit direct biological activities, attenuated LPS-induced VCAM-1 expression by interfering with NF-kappaB and AP-1 activation, and significantly reduced LPS-induced immune cell infiltration of the synovium. PMID: 24628691
  93. Data from multiple sites in United States suggest plasma level of VCAM1 can be modulated by diet; up-regulation of plasma VCAM1 correlates with coronary heart disease risk and may serve as marker of vascular endothelial dysfunction in young adults. PMID: 24534074
  94. VCAM-1 level on presentation is a more powerful predictor of Septic encephalopathy in these patients than lactate concentration and other adhesion molecules on admission. PMID: 24883317
  95. Data indicate neither serum vascular cell adhesion molecule-1 (VCAM-1) levels nor serum epithelial cell adhesion molecule (EpCAM) levels were identified to have a prognostic role on either progression-free survival (PFS) and overall survival (OS). PMID: 24891186
  96. Expression of VCAM-1 by the endothelium and the attachment of leukocytes to these cells play major roles in inflammation and cardiovascular disorders. PMID: 24871655
  97. Data indicate that elevated levels of intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were positively associated with preterm delivery independent of usual risk factors. PMID: 24465662
  98. CD36, HBA, NOS3 and VCAM1 variants are associated with chronic haemolysis level in sickle cell anaemia PMID: 24168396
  99. P. gingivalis induced IL-6, IL-8, and VCAM-1 expression in hGFs and hPDLCs through NOD1/2-mediated NF-kappaB and ERK1/2 signaling pathways. PMID: 24162780
  100. Results of this study demonstrate that the TLR4/NF-kappaB signaling pathway has an important function in the up-regulation of oxLDL-induced expressions of LOX-1, MCP-1, and VCAM-1 in HUVECs. PMID: 24615033

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Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
Database Links

HGNC: 12663

OMIM: 192225

KEGG: hsa:7412

STRING: 9606.ENSP00000294728

UniGene: Hs.109225

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