Mouse Cluster of differentiation 30,CD30 ELISA Kit

Code CSB-E04525m
Size 96T,5×96T,10×96T
Price Request a Quote or Start an on-line Chat
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Product Details

Target Name
tumor necrosis factor receptor superfamily, member 8
Alternative Names
Tnfrsf8 ELISA Kit; Tumor necrosis factor receptor superfamily member 8 ELISA Kit; CD30L receptor ELISA Kit; Lymphocyte activation antigen CD30 ELISA Kit; CD antigen CD30 ELISA Kit
Abbreviation
TNFRSF8
Uniprot No.
Species
Mus musculus (Mouse)
Detection Range
Request Information
Sensitivity
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Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Others
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

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Target Background

Function
(From Uniprot)
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Gene References into Functions
  1. This study demonstrated the amelioration of MOG35-55 peptide-induced active EAE in CD30 KO mice. CD30 was expressed limitedly on CD4 T cells at the induction phase of experimental autoimmune encephalomyelitis. PMID: 26857493
  2. Data indicate that CD30L/CD30 axis plays a modulatory role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). PMID: 25533628
  3. role in the maintenance and activation of IL-17A-producing gammadelta T cells PMID: 23549449
  4. These results suggest that CD30 signaling plays an important role in the activation of IL-17A-producing Vgamma1(-) Vgamma4(-) gammadelta T cells bearing Vgamma6 at an early stage of BCG infection. PMID: 23918785
  5. Interference of the CD30-CD30L pathway reduces atherosclerosis development. PMID: 23087358
  6. CD30L/CD30 pathway acts as an accelerator of enteritis in a murine disease model PMID: 22451116
  7. role of CD30L/CD30 interactions in allergic rhinitis; results suggest that CD30L plays an important role in allergic rhinitis PMID: 21739429
  8. Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice. PMID: 21788408
  9. Studies demonstrate that CD30L/CD30 signaling executed by the T-T cell interaction plays a critical role in Th17 cell differentiation. PMID: 20639486
  10. CD30 can signal in a completely TCR-independent fashion to induce IL-13 production by effector T cells. PMID: 12193714
  11. Immunity to CD30 could play a role in Marek disease lymphoma regression. PMID: 15356338
  12. Deficiencies in OX40 and CD30 signals were additive, secondary Ab responses were ablated.OX40/CD30 double-knockout OTII transgenic T cells fail to survive compared with normal T cells when cocultured with CD4(+)CD3(-) cells in vitro. PMID: 15778343
  13. CD30 plays an important role in the generation of long-lived memory CD8+ T cells, at least partly by triggering homing receptors for T(central memory) cells. PMID: 16177108
  14. early CD30 signaling is critical for regulatory T cells-mediated acute graft-versus-host disease protection after major MHC-mismatch bone marrow transplantation PMID: 17068147
  15. These results indicate that CD30 is a regulator of T(h)2 responses in the effector-memory phase and a regulator of IL-13 production in memory cells in the lung. PMID: 18089617
  16. CD30L/CD30 signaling is involved in development of both OXA- and TNBS-induced colitis. Modulation of CD30L/CD30 signaling by mAb could be a novel biologic therapy for inflammatory bowel diseases. PMID: 18242212
  17. CD30 and OX40 signals are both required for the survival but not commitment of CD4 T helper type 1 (Th1) cells. PMID: 18292503
  18. Signaling executed by CD30positive T cell interaction with CD30Lpositive T cells plays a critical role in amplification of T helper type (Th)1 responses that able to produce interferon-gamma against Mycobacterium bovis bacillus Calmette-Guerin infection. PMID: 18941223
  19. ko mice exhibite delayed structuring of pulmonary granulomas and reduced recruitment of lymphocytes after infection with erogenic Mycobacterium avium PMID: 19250702
  20. CD30 signals from lymphoid tissue inducer cells were a primitive mechanism to recruit and prime CD4 T cells PMID: 19342654
  21. Data demonstrate that the crucial role of CD30 signaling in the development of acute asthma may be taken over by other costimulatory molecules like OX40 after long-term exposure to the antigen. PMID: 19544310
  22. Following infection with murine cytomegalovirus, CD30 is necessary for preserving the lymphoid microenvironment by enhancing the protective function of NK cells. PMID: 19731363
  23. signals through CD30 and OX40 are required for the survival of CD4(+) T cells within the small intestine lamina propria. PMID: 19786532

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Detected in thymus and in activated splenocytes.
Database Links
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