Recombinant Human Hepatocyte growth factor(HGF) (Active)

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Code CSB-AP003681HU
Product Type Growth Factor
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Uniprot No. P14210
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Storage Buffer Lyophilized from a 0.2 μm Filtered 20 mM Tris-HCl, 150 mM NaCl, pH 8.0
Alias Hepatocyte growth factor;HPTA;HGF;;SF;Scatter factor;Hepatopoietin-A
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined by its ability to induce IL-11 secretion by Saos?2 human osteosarcoma cells is less than 10 ng/ml.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Cancer
Source Mammalian cell
Gene Names HGF
Expression Region 32-728aa
Tag Info C-terminal 6xHis-tagged
Mol. Weight 79.7 kDa
Protein Description Full Length of Mature Protein
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Function Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
Involvement in disease Deafness, autosomal recessive, 39 (DFNB39)
Protein Families Peptidase S1 family, Plasminogen subfamily
Database Links

HGNC: 4893

OMIM: 142409

KEGG: hsa:3082

STRING: 9606.ENSP00000222390

UniGene: Hs.396530

Pathway MAPK signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Ras signaling pathway
Rap1 signaling pathway

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