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| Code | CSB-AP005271HU |
| Product Type | Immune Checkpoint |
| Size |
$91Purchase it in Cusabio online store (Shop online in the US. Customers outside the US, please order from local distributors.) |
| Uniprot No. | P78324 |
| Image |
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| Storage Buffer | Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.2 |
| Alias | Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; SHP Substrate 1; SHPS-1; Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs; Bit; CD172 Antigen-Like Family Member A; Inhibitory Feceptor SHPS-1; Macrophage Fusion Receptor; MyD-1 Antigen; Signal-Regulatory Protein Alpha-1; Sirp-Alpha-1; Signal-Regulatory Protein Alpha-2; Sirp-Alpha-2; Signal-Regulatory Protein Alpha-3; Sirp-Alpha-3; p84; CD172a; SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP |
| Species | Homo sapiens (Human) |
| Biological_Activity | The ED50 as determined by its ability to bind Human CD47 in functional ELISA is less than 0.5 ug/ml |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | EEELQVIQPDKSVLVAAGETATLRCTATSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRIGNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNTAAENTGSNER |
| Research Area | Cardiovascular |
| Source | Mammalian cell |
| Gene Names | SIRPA |
| Expression Region | 31-370aa |
| Tag Info | C-terminal 6xHis-tagged |
| Mol. Weight | 38.31 kDa |
| Protein Description | Partial |
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| Function | Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. |
| Subcellular Location | Membrane, Single-pass type I membrane protein |
| Tissue Specificity | Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. |
| Database Links |
HGNC: 9662 OMIM: 602461 KEGG: hsa:140885 STRING: 9606.ENSP00000348307 UniGene: Hs.581021 |
| Pathway | Osteoclast differentiation |
SIRPA Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA021334GA01HU | SIRPA Antibody | Human | ELISA,WB |
| CSB-PA021334LB01HU | SIRPA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA021334LC01HU | SIRPA Antibody, FITC conjugated | Human | ELISA |
| CSB-PA021334LD01HU | SIRPA Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA973893 | SIRPA Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
SIRPA Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA021334LA01HU | SIRPA Antibody | Human | ELISA, IHC, IF |
SIRPA Antibodies for
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA004094 | SIRPA Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
SIRPA Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-MP021334HU | Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA),partial | Mammalian cell |
| CSB-MP021334HUh6 | Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA),partial | Mammalian cell |
| CSB-YP021334HU CSB-BP021334HU |
Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA),partial | Yeast Baculovirus |
| CSB-EP021334HU | Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA),partial | E.coli |
| CSB-CF021334HU | Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA) | in vitro E.coli expression system |
SIRPA ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL021334HU | Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.039 ng/mL |
Recombinant Human Indoleamine 2,3-dioxygenase 1(IDO1)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Interferon-induced, double-stranded RNA-activated protein kinase(EIF2AK2)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human MARCKS-related protein(MARCKSL1)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1(ART1)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Plasma kallikrein(KLKB1),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Mouse Collagen alpha-2(IV) chain(Col4a2),partial
Express system: Yeast
Species: Mus musculus (Mouse)
