Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA),partial

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Code	CSB-AP005271HU
Product Type	Immune Checkpoint
Size	US$91
Uniprot No.	P78324
Lead Time	5-10 business days
Storage Buffer	Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.2
Alias	Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; SHP Substrate 1; SHPS-1; Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs; Bit; CD172 Antigen-Like Family Member A; Inhibitory Feceptor SHPS-1; Macrophage Fusion Receptor; MyD-1 Antigen; Signal-Regulatory Protein Alpha-1; Sirp-Alpha-1; Signal-Regulatory Protein Alpha-2; Sirp-Alpha-2; Signal-Regulatory Protein Alpha-3; Sirp-Alpha-3; p84; CD172a; SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP
Species	Homo sapiens (Human)
Biological_Activity	The ED50 as determined by its ability to bind Human CD47 in functional ELISA is less than 0.5 ug/ml
Purity	Greater than 95% as determined by SDS-PAGE.
Endotoxin	Less than 1.0 EU/μg as determined by LAL method.
Sequence	EEELQVIQPDKSVLVAAGETATLRCTATSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRIGNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNTAAENTGSNER
Research Area	Cardiovascular
Source	Mammalian cell
Gene Names	SIRPA
Expression Region	31-370aa
Tag Info	C-terminal 6xHis-tagged
Mol. Weight	38.31 kDa
Protein Description	Partial
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Function	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Subcellular Location	Membrane, Single-pass type I membrane protein
Tissue Specificity	Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
Database Links	HGNC: 9662 OMIM: 602461 KEGG: hsa:140885 STRING: 9606.ENSP00000348307 UniGene: Hs.581021
Pathway	Osteoclast differentiation

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SIRPA ELISA Kit for Homo sapiens (Human)

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SIRPA ELISA Kit for Mus musculus (Mouse)

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CSB-EL021334MO	Mouse Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA) ELISA kit	serum, plasma, tissue homogenates	7.8 pg/mL

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