Recombinant Mouse Cytotoxic T-lymphocyte protein 4(Ctla4),partial (Active)

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Code CSB-AP005301MO
Product Type Immune Checkpoint
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Uniprot No. P09793
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Storage Buffer Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
Alias Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; Ctla4
Species Mus musculus (Mouse)
Biological_Activity The ED50 as determined by its ability to bind Mouse B7-1 in functional ELISA is less than 20 ng/ml.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Immunology
Source Mammalian cell
Gene Names Ctla4
Expression Region 37-161aa
Tag Info C-terminal 6xHis-tagged
Mol. Weight 14.6 kDa
Protein Description Partial
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Function Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Subcellular Location Cell membrane, Single-pass type I membrane protein
Tissue Specificity Widely expressed with highest levels in lymphoid tissues.
Database Links

KEGG: mmu:12477

STRING: 10090.ENSMUSP00000027164

UniGene: Mm.390

Pathway T cell receptor signaling pathway

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