Recombinant Human Interleukin-33 protein(IL33) (Active)

In Stock
Code CSB-AP001911HU
Product Type Interleukin
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. O95760
Lead Time 5-10 business days
Image
Storage Buffer 0.2μm filtered 20 mM PB, 150 mM NaCl, 1mM EDTA, pH7.4 ,lyophilized
Alias IL-33, IL-1F11, Nuclear factor from high endothelial venules, NF-HEV
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.05 ng/ml, corresponding to a specific activity of >2.0x107 IU/mg.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence SITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVLLSYYESQHPS NE SGDGVDGK MLMVTLSPTK DFWLHANNKE HSVELHKCEKPLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET
Research Area Immunology
Source E.coli
Gene Names IL33
Expression Region 112-270aa
Tag Info Tag-Free
Mol. Weight 17.9 kDa
Protein Description Partial
PubMed ID 12819012; 10566975; 16286016; 21454686; 14702039; 15164053; 15489334; 22307629; 17853410; 17185418; 18787100; 18836528; 19596270; 19559631; 19465481; 19439663; 21734074; 22215666; 19836339; 23980170
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Function Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells
Subcellular Location Nucleus, Chromosome, Cytoplasmic vesicle, secretory vesicle, Secreted
Protein Families IL-1 family
Tissue Specificity Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
Database Links

HGNC: 16028

OMIM: 608678

KEGG: hsa:90865

STRING: 9606.ENSP00000370842

UniGene: Hs.731660

Pathway Necroptosis

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