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| Code | CSB-AP002051HU |
| Product Type | Interleukin |
| Size |
US$112Purchase it in Cusabio online store (only available for customers from the US) |
| Uniprot No. | Q9UBH0 |
| Lead Time | 5-10 business days |
| Image | |
| Storage Buffer | 0.2 μm filtered PBS, pH 7.4 ,lyophilized |
| Alias | IL-36Ra, IL-1-related protein 3, IL-1RP3, Interleukin-1 HY1, IL-1HY1 |
| Species | Homo sapiens (Human) |
| Biological_Activity | Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-36 beta induced IL-8 secretion by human preadipocytes is less than 1.0 μg/ml, corresponding to a specific activity of >1000 IU/mg in the presence of 20 ng/ml of recombinant human IL-36 beta. |
| Purity | >95% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAGKVIKGEE ISVVPNRWLD ASLSPVILGV QGGSQCLSCG VGQEPTLTLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTVPEADQPV RLTQLPENGG WNAPITDFYF QQCD |
| Research Area | Immunology |
| Source | E.coli |
| Gene Names | IL36RN |
| Expression Region | 2-155aa |
| Tag Info | Tag-Free |
| Mol. Weight | 16.8 kDa |
| Protein Description | Full Length of Mature Protein |
| PubMed ID | 10625660; 10512743; 11093146; 11466363; 10860666; 11991722; 12975309; 14702039; 15815621; 15489334; 21965679; 23147407; 21839423; 21848462; 22903787 |
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| Function | Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. |
| Involvement in disease | Psoriasis 14, pustular (PSORS14) |
| Subcellular Location | Secreted |
| Protein Families | IL-1 family |
| Tissue Specificity | Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. |
| Database Links |
HGNC: 15561 OMIM: 605507 KEGG: hsa:26525 STRING: 9606.ENSP00000259212 UniGene: Hs.516301 |
IL36RN Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA866201HA01HU | IL36RN Antibody | Human, Mouse, Rat | ELISA, WB |
| CSB-PA866201DSR1HU | IL36RN Antibody | Human | ELISA, IHC |
IL36RN Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA866201HB01HU | IL36RN Antibody, HRP conjugated | Human | ELISA |
| CSB-PA866201HC01HU | IL36RN Antibody, FITC conjugated | Human | ELISA |
| CSB-PA866201HD01HU | IL36RN Antibody, Biotin conjugated | Human | ELISA |
IL36RN Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-AP004411HU | Recombinant Human Interleukin-36 receptor antagonist protein(IL36RN) | E.coli |
| CSB-YP866201HU CSB-BP866201HU CSB-MP866201HU |
Recombinant Human Interleukin-36 receptor antagonist protein(IL36RN) | Yeast Baculovirus Mammalian cell |
| CSB-EP866201HU | Recombinant Human Interleukin-36 receptor antagonist protein(IL36RN) | E.coli |
IL36RN ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL011616HU | Human Interleukin-36 receptor antagonist protein(IL1F5) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 1.95 pg/mL |
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Recombinant Human Ras-related protein Rab-5C(RAB5C)
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Recombinant Human Retinol-binding protein 2(RBP2)
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Recombinant Rat Allograft inflammatory factor 1(Aif1)
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Recombinant Human Ribose-phosphate pyrophosphokinase 1(PRPS1)
Express system: E.coli
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Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Chromobox protein homolog 7(CBX7)
Express system: E.coli
Species: Homo sapiens (Human)
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