Code | CSB-MA017667A0m |
Size | US$350 |
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Description |
CUSABIO immunized the mouse with the recombinant human PD-L2 protein (21-118AA) to get the splenocytes that secret the PD-L2 antibody. The PD-L2-producing splenocytes were subsequently fused with myeloma cells to form hybridomas, which were inoculated into the abdominal cavity of mice. The mouse ascites was collected and purified to get the monoclonal anti-PD-L2 antibody. Following purification through protein A, the purity of the monoclonal PD-L2 antibody is more than 95%. It is matched with the mouse IgG2b isotype. And it targets PD-L2 in ELISA, WB, IHC, IP, IF, and FC applications and reacts with human samples. Programmed cell death ligand 2 (PD-L2) is the second ligand of PD-1. Upon the binding to the PD-1 receptor, PD-L2 contributes to T-cell exhaustion. Contrary to PD-L1, PD-L2 is restricted to antigen-presenting cells (APCs), including dendritic cells, macrophages, monocytes, and some B cells. PD-L2 plays an important role in immune tolerance and autoimmunity. |
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Full Product Name | Mouse anti-Human PD-L2 Monoclonal Antibody antibody | ||||||||||||
Uniprot No. | Q9BQ51 | ||||||||||||
Target Names | PD-L2 | ||||||||||||
Alternative Names |
B7 dendritic cell molecule antibody; B7-DC antibody; B7DC antibody; bA574F11.2 antibody; Btdc antibody; Butyrophilin B7 DC antibody; Butyrophilin B7-DC antibody; Butyrophilin B7DC antibody; CD 273 antibody; CD273 antibody; CD273 antigen antibody; MGC142238 antibody; MGC142240 antibody; PD 1 ligand 2 antibody; PD L2 antibody; PD-1 ligand 2 antibody; PD-L2 antibody; PD1 ligand 2 antibody; PD1L2_HUMAN antibody; PDCD 1 ligand 2 antibody; PDCD1 ligand 2 antibody; PDCD1L2 antibody; Pdcd1lg2 antibody; PDL 2 antibody; PDL2 antibody; Programmed cell death 1 ligand 2 antibody; Programmed death ligand 2 antibody
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Raised in | Mouse | ||||||||||||
Species Reactivity | Human | ||||||||||||
Immunogen | Recombinant Human Programmed cell death 1 ligand 2 protein (21-118AA) | ||||||||||||
Immunogen Species | Human | ||||||||||||
Conjugate | Non-conjugated | ||||||||||||
Clonality | Monoclonal Antibody | ||||||||||||
Isotype | IgG2b | ||||||||||||
Clone No. | 7F11D11 | ||||||||||||
Purification Method | >95%,Protein A purified | ||||||||||||
Concentration | It differs from different batches. Please contact us to confirm it. | ||||||||||||
Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
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Form | Liquid | ||||||||||||
Tested Applications | ELISA, WB, IHC, IF, FC, IP | ||||||||||||
Recommended Dilution |
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Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol Flow Cytometry (FC) Protocol Immunoprecipitation (IP) Protocol |
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Troubleshooting and FAQs | Antibody FAQs | ||||||||||||
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||||||||
Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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Function |
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
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Gene References into Functions |
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Subcellular Location | [Isoform 3]: Secreted.; [Isoform 2]: Endomembrane system; Single-pass type I membrane protein.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. |
Protein Families | Immunoglobulin superfamily, BTN/MOG family |
Tissue Specificity | Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. |
Database Links |
HGNC: 18731 OMIM: 605723 KEGG: hsa:80380 STRING: 9606.ENSP00000380855 UniGene: Hs.532279 |