TUBB2A Monoclonal Antibody

Code CSB-MA000312
Size US$100
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  • 1) Input: Mouse Brain Tissue Lysate 2) IP product: IP dilute 1: 200 Western blot analysis: primary antibody : 1: 10000 Secondary antibody: Goat anti-Mouse IgG, Light chain specific (S003), 1: 5000

  • Western blot analysis of 1) Mouse Brain tissue, 2) Rat Brain tissue, diluted at 1:100000.

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Product Details

Uniprot No.
Target Names
TUBB2A
Alternative Names
TUBB2A antibody; TUBB2 antibody; Tubulin beta-2A chain antibody; Tubulin beta class IIa antibody
Raised in
Mouse
Species Reactivity
Mouse,Rat,Human
Immunogen
Synthetic Peptide
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form
Liquid
Tested Applications
ELISA,WB,IP
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IP 1:200-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene References into Functions
  1. TUBB2A missense mutation is associated with arthrogryposis multiplex congenita, brain abnormalities, and severe developmental delay. PMID: 28840640
  2. study associates mutations in TUBB2A with the spectrum of "tubulinopathy" phenotypes PMID: 24702957
  3. This is the first study showing that paclitaxel neuropathy risk is influenced by polymorphisms regulating the expression of a beta-tubulin gene. PMID: 22718863
  4. Class II beta-tubulin may be very useful for immunohistochemical diagnosis of classical Hodgkin's lymphoma. PMID: 22449234
  5. Data suggest that the increased betaII- and betaIII-tubulin contributed significantly to the resistance phenotype. PMID: 22180309
  6. lack of mutations in early stage lung cancer PMID: 12209967
  7. Mutations of the beta-tubulin gene, which might be a contraindication for chemotherapy based on taxans, were very rare events in gastric cancer. PMID: 12861402

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Involvement in disease
Cortical dysplasia, complex, with other brain malformations 5 (CDCBM5)
Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
Tubulin family
Tissue Specificity
High expression in brain, where it represents 30% of all beta-tubulins.
Database Links

HGNC: 12412

OMIM: 615101

KEGG: hsa:7280

STRING: 9606.ENSP00000369703

UniGene: Hs.654543

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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