TUBB2A Antibody

Code CSB-PA025320LA01HU
Size US$166
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  • Western blot
    All lanes: TUBB2A antibody at 14µg/ml
    Lane 1: MCF-7 whole cell lysate
    Lane 2: Hela whole cell lysate
    Lane 3: HepG2 whole cell lysate
    Lane 4: MDA-MB-231 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 50 kDa
    Observed band size: 50 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TUBB2A Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
TUBB2A antibody; TUBB2 antibody; Tubulin beta-2A chain antibody; Tubulin beta class IIa antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tubulin beta-2A chain protein (1-445AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TUBB2A Antibody (Product code: CSB-PA025320LA01HU) is Non-conjugated. For TUBB2A Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA025320LB01HU TUBB2A Antibody, HRP conjugated ELISA
FITC CSB-PA025320LC01HU TUBB2A Antibody, FITC conjugated
Biotin CSB-PA025320LD01HU TUBB2A Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene References into Functions
  1. TUBB2A missense mutation is associated with arthrogryposis multiplex congenita, brain abnormalities, and severe developmental delay. PMID: 28840640
  2. study associates mutations in TUBB2A with the spectrum of "tubulinopathy" phenotypes PMID: 24702957
  3. This is the first study showing that paclitaxel neuropathy risk is influenced by polymorphisms regulating the expression of a beta-tubulin gene. PMID: 22718863
  4. Class II beta-tubulin may be very useful for immunohistochemical diagnosis of classical Hodgkin's lymphoma. PMID: 22449234
  5. Data suggest that the increased betaII- and betaIII-tubulin contributed significantly to the resistance phenotype. PMID: 22180309
  6. lack of mutations in early stage lung cancer PMID: 12209967
  7. Mutations of the beta-tubulin gene, which might be a contraindication for chemotherapy based on taxans, were very rare events in gastric cancer. PMID: 12861402

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Involvement in disease
Cortical dysplasia, complex, with other brain malformations 5 (CDCBM5)
Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
Tubulin family
Tissue Specificity
High expression in brain, where it represents 30% of all beta-tubulins.
Database Links

HGNC: 12412

OMIM: 615101

KEGG: hsa:7280

STRING: 9606.ENSP00000369703

UniGene: Hs.654543

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