Recombinant Human Plasminogen protein(PLG) (Active)

Code CSB-AP002261HU
Product Type Other
Size Pls inquiry other sizesPurchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P00747
Image
Storage Buffer 0.2 μm filtered 20 mM NaAc, pH 5.5, 4 % mannitol ,lyophilized
Alias EC 3.4.21.7
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells in vitro and anti-angiogenesis in vivo is 5.5x105 IU/mg.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLK GTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSSP
Research Area Cancer
Source E.coli
Gene Names PLG
Expression Region 98-356aa
Product Info Tag-Free
Mol. Weight 29.7 kDa
Protein Description Partial
PubMed ID 2318848; 3030813; 14574404; 15489334; 122932; 6148961; 126863; 142009; 4694729; 4240117; 6919539; 6094526; 9201958; 3356193; 9102401; 9054441; 7525077; 9102221; 9548733; 10077593; 10889192; 14699093; 16043488; 18780401; 2143188; 19712047; 24275569; 165714
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Function Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Involvement in disease Plasminogen deficiency (PLGD)
Subcellular Location Secreted
Protein Families Peptidase S1 family, Plasminogen subfamily
Tissue Specificity Present in plasma and many other extracellular fluids. It is synthesized in the liver.
Database Links

HGNC: 9071

OMIM: 173350

KEGG: hsa:5340

STRING: 9606.ENSP00000308938

UniGene: Hs.143436

Pathway Complement and coagulation cascades

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