ADCY1 Antibody

Code CSB-PA001336GA01HU
Size US$685
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Product Details

Uniprot No. Q08828
Target Names ADCY1
Alternative Names Adenylate cyclase 1; fetal brain; type I antibody; 3',5'-cyclic AMP synthetase antibody; AC1 antibody; Adcy1 antibody; ADCY1_HUMAN antibody; adenyl cyclase antibody; Adenylate cyclase 1 antibody; adenylate cyclase 1 (brain) antibody; Adenylate cyclase type 1 antibody; Adenylate cyclase type I antibody; Adenylyl cyclase 1 antibody; ATP pyrophosphate lyase antibody; ATP pyrophosphate-lyase 1 antibody; Brain adenylate cyclase 1 antibody; Ca(2+)/calmodulin-activated adenylyl cyclase antibody; deafness; autosomal recessive 44 antibody; DFNB44 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human ADCY1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer 0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

(From Uniprot)
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels. May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina.
Gene References into Functions
  1. data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain. PMID: 28223412
  2. Data show that the adenylate cyclase (AC) pathway as genes relating to the antitumor activity of xanthohumol (XN) against tumor cells, and the pathway regulates various cellular functions via activating protein kinase A (PKA)-dependent phosphorylation. PMID: 28122154
  3. Maps to 7p14.1-q11.22 between D7S2209 and marker D7S2435, maximum Lod score 5 for D7S1818. PMID: 15583425
  4. STC1 interferes with CALCRL signaling during osteoblastogenesis via adenylate cyclase inhibition. PMID: 25591908
  5. AC1 catalytic activity can be adjusted by mediating calmodulin activation of AC1 by reversible methionine oxidation in calmodulin. PMID: 25462816
  6. Increased expression of AC1 in the forebrain leads to deficits in behavioral inhibition. PMID: 25568126
  7. AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2. PMID: 23504261
  8. Compartmentalized AC1-CFTR association is responsible for Ca(2+)/cAMP cross-talk. PMID: 20554763
  9. Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation. PMID: 12743114
  10. Transgenic mice overexpressing type-1 adenylyl cyclase in the forebrain show elevated long-term potentiation (LTP), increased memory for object recognition and slower rates of extinction for contextual memory. PMID: 15133516
  11. Expression of sensitization of AC1 involves Galpha(s)-adenylyl cyclase interactions. PMID: 15361543
  12. These results suggest a possible role of APLP1 in regulation of alpha2A-adrenergic receptor trafficking. PMID: 16531006
  13. Fully differentiated human airway epithelial cells in culture are shown to express calcium-stimulated transmembrane adenylyl cyclase (tmAC) isoforms (types 1, 3, and 8) by reverse transcription polymerase chain reaction. PMID: 17586501
  14. Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. PMID: 19029295
  15. Young transgenic mice overexpressing AC1 in the forebrain (AC1+ mice) have enhanced hippocampal long-term potentiation, superior memory for novel object recognition and more persistent remote contextual memory. PMID: 19726641

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Involvement in disease Deafness, autosomal recessive, 44 (DFNB44)
Subcellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane raft.
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Brain, retina and adrenal medulla.
Database Links

HGNC: 232

OMIM: 103072

KEGG: hsa:107

STRING: 9606.ENSP00000297323

UniGene: Hs.192215


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