ADCY1 Antibody, Biotin conjugated

1. data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain. PMID: 28223412
2. Data show that the adenylate cyclase (AC) pathway as genes relating to the antitumor activity of xanthohumol (XN) against tumor cells, and the pathway regulates various cellular functions via activating protein kinase A (PKA)-dependent phosphorylation. PMID: 28122154
3. Maps to 7p14.1-q11.22 between D7S2209 and marker D7S2435, maximum Lod score 5 for D7S1818. PMID: 15583425
4. STC1 interferes with CALCRL signaling during osteoblastogenesis via adenylate cyclase inhibition. PMID: 25591908
5. AC1 catalytic activity can be adjusted by mediating calmodulin activation of AC1 by reversible methionine oxidation in calmodulin. PMID: 25462816
6. Increased expression of AC1 in the forebrain leads to deficits in behavioral inhibition. PMID: 25568126
7. AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2. PMID: 23504261
8. Compartmentalized AC1-CFTR association is responsible for Ca(2+)/cAMP cross-talk. PMID: 20554763
9. Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation. PMID: 12743114
10. Transgenic mice overexpressing type-1 adenylyl cyclase in the forebrain show elevated long-term potentiation (LTP), increased memory for object recognition and slower rates of extinction for contextual memory. PMID: 15133516
11. Expression of sensitization of AC1 involves Galpha(s)-adenylyl cyclase interactions. PMID: 15361543
12. These results suggest a possible role of APLP1 in regulation of alpha2A-adrenergic receptor trafficking. PMID: 16531006
13. Fully differentiated human airway epithelial cells in culture are shown to express calcium-stimulated transmembrane adenylyl cyclase (tmAC) isoforms (types 1, 3, and 8) by reverse transcription polymerase chain reaction. PMID: 17586501
14. Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. PMID: 19029295
15. Young transgenic mice overexpressing AC1 in the forebrain (AC1+ mice) have enhanced hippocampal long-term potentiation, superior memory for novel object recognition and more persistent remote contextual memory. PMID: 19726641

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HGNC: 232

OMIM: 103072

KEGG: hsa:107

STRING: 9606.ENSP00000297323

UniGene: Hs.192215