ADCY1 Antibody

Datasheet

Code	CSB-PA000773
Size	US$119
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Image	Western Blot analysis of COLO205 cells using A Cyclase I Polyclonal Antibody Western Blot analysis of HuvEc MCF7 cells using A Cyclase I Polyclonal Antibody
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q08828

Target Names

ADCY1

Alternative Names

Adenylate cyclase 1; fetal brain; type I antibody; 3',5'-cyclic AMP synthetase antibody; AC1 antibody; Adcy1 antibody; ADCY1_HUMAN antibody; adenyl cyclase antibody; Adenylate cyclase 1 antibody; adenylate cyclase 1 (brain) antibody; Adenylate cyclase type 1 antibody; Adenylate cyclase type I antibody; Adenylyl cyclase 1 antibody; ATP pyrophosphate lyase antibody; ATP pyrophosphate-lyase 1 antibody; Brain adenylate cyclase 1 antibody; Ca(2+)/calmodulin-activated adenylyl cyclase antibody; deafness; autosomal recessive 44 antibody; DFNB44 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the Internal region of Human A Cyclase I.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels. May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina.

Gene References into Functions

data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain. PMID: 28223412
Data show that the adenylate cyclase (AC) pathway as genes relating to the antitumor activity of xanthohumol (XN) against tumor cells, and the pathway regulates various cellular functions via activating protein kinase A (PKA)-dependent phosphorylation. PMID: 28122154
Maps to 7p14.1-q11.22 between D7S2209 and marker D7S2435, maximum Lod score 5 for D7S1818. PMID: 15583425
STC1 interferes with CALCRL signaling during osteoblastogenesis via adenylate cyclase inhibition. PMID: 25591908
AC1 catalytic activity can be adjusted by mediating calmodulin activation of AC1 by reversible methionine oxidation in calmodulin. PMID: 25462816
Increased expression of AC1 in the forebrain leads to deficits in behavioral inhibition. PMID: 25568126
AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2. PMID: 23504261
Compartmentalized AC1-CFTR association is responsible for Ca(2+)/cAMP cross-talk. PMID: 20554763
Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation. PMID: 12743114
Transgenic mice overexpressing type-1 adenylyl cyclase in the forebrain show elevated long-term potentiation (LTP), increased memory for object recognition and slower rates of extinction for contextual memory. PMID: 15133516
Expression of sensitization of AC1 involves Galpha(s)-adenylyl cyclase interactions. PMID: 15361543
These results suggest a possible role of APLP1 in regulation of alpha2A-adrenergic receptor trafficking. PMID: 16531006
Fully differentiated human airway epithelial cells in culture are shown to express calcium-stimulated transmembrane adenylyl cyclase (tmAC) isoforms (types 1, 3, and 8) by reverse transcription polymerase chain reaction. PMID: 17586501
Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. PMID: 19029295
Young transgenic mice overexpressing AC1 in the forebrain (AC1+ mice) have enhanced hippocampal long-term potentiation, superior memory for novel object recognition and more persistent remote contextual memory. PMID: 19726641

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Involvement in disease

Deafness, autosomal recessive, 44 (DFNB44)

Subcellular Location

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane raft.

Protein Families

Adenylyl cyclase class-4/guanylyl cyclase family

Tissue Specificity

Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Brain, retina and adrenal medulla.

Database Links

HGNC: 232

OMIM: 103072

KEGG: hsa:107

STRING: 9606.ENSP00000297323

UniGene: Hs.192215

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Calcium signaling pathway cAMP signaling pathway Chemokine signaling pathway Estrogen signaling pathway Melanogenesis Gap junction Vascular smooth muscle contraction Th17 cell differentiation Thyroid hormone synthesis Apelin signaling pathway cGMP-PKG signaling pathway Oxidative Phosphorylation Phospholipase D signaling pathway Rap1 signaling pathway Glutamatergic synapse

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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