APAF1 Antibody

Datasheet
Code CSB-PA001885GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. O14727
Immunogen Human APAF1
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias apoptotic peptidase activating factor 1;APAF1;APAF-1;CED4;DKFZp781B1145 ;
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names APAF1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
HGNC 17581
RGD 1564562
MGI 1926788
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Function Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Subcellular Location Cytoplasm
Tissue Specificity Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
Database Links

HGNC: 576

OMIM: 602233

KEGG: hsa:317

STRING: 9606.ENSP00000448165

UniGene: Hs.552567

Pathway p53 signaling pathway
Apoptosis

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