APAF1 Antibody

Datasheet
Code CSB-PA005612
Size US$167
Uniprot No. O14727
Image
  • Western Blot analysis of K562 cells using Apaf-1 Polyclonal Antibody.
Immunogen Synthesized peptide derived from the Internal region of Human Apaf-1.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB,ELISA;WB:1/500-1/2000.ELISA:1/20000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1
Immunogen Species Homo sapiens (Human)
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Target Names APAF1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Subcellular Location Cytoplasm
Tissue Specificity Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
Database Links

HGNC: 576

OMIM: 602233

KEGG: hsa:317

STRING: 9606.ENSP00000448165

UniGene: Hs.552567

Pathway p53 signaling pathway
Apoptosis

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