APAF1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA001885LD01HU
Size US$299
Uniprot No. O14727
Protocols ELISA Protocol
Immunogen Recombinant Human Apoptotic protease-activating factor 1 protein (104-415AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Apoptotic protease-activating factor 1 (APAF-1), APAF1, KIAA0413
Immunogen Species Homo sapiens (Human)
Research Area Cell Biology
Target Names APAF1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Subcellular Location Cytoplasm
Tissue Specificity Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
Database Links

HGNC: 576

OMIM: 602233

KEGG: hsa:317

STRING: 9606.ENSP00000448165

UniGene: Hs.552567

Pathway p53 signaling pathway
Apoptosis

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