AR (Ab-363) Antibody

Datasheet
Code CSB-PA082237
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P10275
Image
  • Western blot analysis of extracts from K562 cells, treated with EGF (200ng/ml, 5mins), using Androgen Receptor (Ab-363) antibody.
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Synthesized non-phosphopeptide derived from Human Androgen Receptor around the phosphorylation site of tyrosine 363 (D-Y-Y(p)-N-F).
Raised in Rabbit
Species Reactivity Human,Mouse
Specificity The antibody detects endogenous levels of total Androgen Receptor protein.
Tested Applications ELISA,WB;WB:1:500-1:3000
Relevance Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.

Lubahn D.B., Mol. Endocrinol. 2:1265-1275(1988).
Lubahn D.B., Proc. Natl. Acad. Sci. U.S.A. 86:9534-9538(1989).
Govindan M.V.; Mol. Endocrinol. 4:417-427(1990).
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias ANDR; Androgen receptor; DHTR; Dihydrotestosterone receptor; NR3C4
Immunogen Species Homo sapiens (Human)
Target Names AR
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Involvement in disease Androgen insensitivity syndrome (AIS); Spinal and bulbar muscular atrophy X-linked 1 (SMAX1); Androgen insensitivity, partial (PAIS)
Subcellular Location Nucleus, Cytoplasm
Protein Families Nuclear hormone receptor family, NR3 subfamily
Tissue Specificity Isoform 2 is mainly expressed in heart and skeletal muscle (PubMed:15634333). Isoform 3 is expressed by basal and stromal cells of prostate (at protein level) (PubMed:19244107).
Database Links

HGNC: 644

OMIM: 300068

KEGG: hsa:367

STRING: 9606.ENSP00000363822

UniGene: Hs.76704

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