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| Code | CSB-PA438009 |
| Former Code(s) | CSB-PA191069 |
| Size | US$299 |
| Uniprot No. | Q8WYN0 |
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
| Immunogen | Synthetic peptide of Human ATG4A |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | ELISA,WB,IHC;ELISA:1:1000-1:5000,WB:1:200-1:1000,IHC:1:50-1:200 |
| Relevance | Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified. |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method | Antigen affinity purification |
| Isotype | IgG |
| Alias | autophagy related 4A, cysteine peptidase |
| Immunogen Species | Homo sapiens (Human) |
| Target Names | ATG4A |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms. |
| Subcellular Location | Cytoplasm |
| Protein Families | Peptidase C54 family |
| Tissue Specificity | Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. |
| Database Links |
HGNC: 16489 OMIM: 300663 KEGG: hsa:115201 STRING: 9606.ENSP00000361306 UniGene: Hs.8763 |
| Pathway | Autophagy |
ATG4A Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA845174EA01HU | ATG4A Antibody | Human, Mouse | ELISA, WB |
ATG4A Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA845174EB01HU | ATG4A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA845174EC01HU | ATG4A Antibody, FITC conjugated | Human | ELISA |
| CSB-PA845174ED01HU | ATG4A Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA006858 | ATG4A Antibody | Human,Mouse | WB,IHC,IF,ELISA |
| CSB-PA547032 | ATG4A Antibody | Human | ELISA,WB,IHC |
| CSB-PA227217 | ATG4A Antibody | Human,Mouse,Rat | IHC,ELISA |
ATG4A Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP845174HU CSB-EP845174HU CSB-BP845174HU CSB-MP845174HU |
Recombinant Human Cysteine protease ATG4A(ATG4A) | Yeast E.coli Baculovirus Mammalian cell |
2-hydroxyisobutyryl-HIST1H3A (K4) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H4A (K16) Antibody
Applications: ELISA, WB, IF, IP, ChIP
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H4A (K8) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
