ATG4A Antibody

^Datasheet

Code	CSB-PA227217
Size	US$167
Uniprot No.	Q8WYN0
Image	Immunohistochemical analysis of paraffin-embedded Human Skeletal Muscle Tissue using ATG4a Rabbit pAb diluted at 1:200 Immunohistochemical analysis of paraffin-embedded Human Brain Tissue using ATG4a Rabbit pAb diluted at 1:200
Immunogen	Recombinant Protein
Raised in	Rabbit
Species Reactivity	Human,Mouse,Rat
Tested Applications	IHC,ELISA;IHC:1/50-1/200.ELISA:1/10000
Form	Liquid
Conjugate	Non-conjugated
Storage Buffer	PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Alias	Cysteine protease ATG4A (EC 3.4.22.-) (AUT-like 2 cysteine endopeptidase) (Autophagin-2) (Autophagy-related cysteine endopeptidase 2) (Autophagy-related protein 4 homolog A) (hAPG4A)
Immunogen Species	Homo sapiens (Human)
Protocols	Immunohistochemistry (IHC) Protocol ELISA Protocol
Target Names	ATG4A
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Subcellular Location	Cytoplasm
Protein Families	Peptidase C54 family
Tissue Specificity	Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.
Database Links	HGNC: 16489 OMIM: 300663 KEGG: hsa:115201 STRING: 9606.ENSP00000361306 UniGene: Hs.8763
Pathway	Autophagy

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ATG4A Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP845174HU CSB-EP845174HU CSB-BP845174HU CSB-MP845174HU	Recombinant Human Cysteine protease ATG4A(ATG4A)	Yeast E.coli Baculovirus Mammalian cell

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