ATG4A Antibody

Code CSB-PA227217
Size US$167
Uniprot No. Q8WYN0
  • Immunohistochemical analysis of paraffin-embedded Human Skeletal Muscle Tissue using ATG4a Rabbit pAb diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded Human Brain Tissue using ATG4a Rabbit pAb diluted at 1:200
Protocols Immunohistochemistry (IHC) Protocol
ELISA Protocol
Immunogen Recombinant Protein
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications IHC,ELISA;IHC:1/50-1/200.ELISA:1/10000
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Alias Cysteine protease ATG4A (EC 3.4.22.-) (AUT-like 2 cysteine endopeptidase) (Autophagin-2) (Autophagy-related cysteine endopeptidase 2) (Autophagy-related protein 4 homolog A) (hAPG4A)
Immunogen Species Homo sapiens (Human)
Target Names ATG4A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Subcellular Location Cytoplasm
Protein Families Peptidase C54 family
Tissue Specificity Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.
Database Links

HGNC: 16489

OMIM: 300663

KEGG: hsa:115201

STRING: 9606.ENSP00000361306

UniGene: Hs.8763

Pathway Autophagy

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