ATG4A

Cysteine protease ATG4A is a protein in humans that is encoded by ATG4A gene. Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.

The following ATG4A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ATG4A Antibodies

ATG4A Proteins

ATG4A Antibodies

ATG4A Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA845174EA01HU	ATG4A Antibody	Human, Mouse	ELISA, WB
CSB-PA006858	ATG4A Antibody	Human,Mouse	WB, IHC, IF, ELISA
CSB-PA438009	ATG4A Antibody	Human	ELISA,WB,IHC
CSB-PA547032	ATG4A Antibody	Human	ELISA,WB,IHC
CSB-PA227217	ATG4A Antibody	Human,Mouse,Rat	IHC, ELISA

ATG4A Antibodies for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Species Reactivity	Application
CSB-PA837318XA01DOA	ATG4A Antibody	Arabidopsis thaliana	ELISA, WB (ensure identification of antigen)

ATG4A Antibodies for Oryza sativa subsp. japonica (Rice)

Code	Product Name	Species Reactivity	Application
CSB-PA751824XA01OFG	ATG4A Antibody	Oryza sativa subsp. japonica (Rice)	ELISA, WB (ensure identification of antigen)

ATG4A Antibodies for Oryza sativa subsp. indica (Rice)

Code	Product Name	Species Reactivity	Application
CSB-PA002289XA01OFF	ATG4A Antibody	Oryza sativa subsp. indica (Rice)	ELISA, WB (ensure identification of antigen)

ATG4A Proteins

ATG4A Proteins for Oryza sativa subsp. indica (Rice)

Code	Product Name	Source
CSB-YP002289OFF CSB-EP002289OFF CSB-BP002289OFF CSB-MP002289OFF CSB-EP002289OFF-B	Recombinant Oryza sativa subsp. indica Cysteine protease ATG4A (ATG4A)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATG4A Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP725290PYX CSB-EP725290PYX CSB-BP725290PYX CSB-MP725290PYX CSB-EP725290PYX-B	Recombinant Pongo abelii Cysteine protease ATG4A (ATG4A)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATG4A Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP733529CH CSB-EP733529CH CSB-BP733529CH CSB-MP733529CH CSB-EP733529CH-B	Recombinant Chicken Cysteine protease ATG4A (ATG4A)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATG4A Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP747507BO CSB-EP747507BO CSB-BP747507BO CSB-MP747507BO CSB-EP747507BO-B	Recombinant Bovine Cysteine protease ATG4A (ATG4A)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATG4A Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP750206XBE CSB-EP750206XBE CSB-BP750206XBE CSB-MP750206XBE CSB-EP750206XBE-B	Recombinant Xenopus laevis Cysteine protease ATG4A (atg4a)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATG4A Proteins for Oryza sativa subsp. japonica (Rice)

Code	Product Name	Source
CSB-YP751824OFG CSB-EP751824OFG CSB-BP751824OFG CSB-MP751824OFG CSB-EP751824OFG-B	Recombinant Oryza sativa subsp. japonica Cysteine protease ATG4A (ATG4A)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATG4A Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP806035MO CSB-EP806035MO CSB-BP806035MO CSB-MP806035MO CSB-EP806035MO-B	Recombinant Mouse Cysteine protease ATG4A (Atg4a)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATG4A Proteins for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Source
CSB-YP837318DOA CSB-EP837318DOA CSB-BP837318DOA CSB-MP837318DOA CSB-EP837318DOA-B	Recombinant Arabidopsis thaliana Cysteine protease ATG4a (ATG4A)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATG4A Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP845174HU CSB-EP845174HU CSB-BP845174HU CSB-MP845174HU CSB-EP845174HU-B	Recombinant Human Cysteine protease ATG4A (ATG4A)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATG4A Background

Cysteine protease ATG4A is a protein in humans that is encoded by the ATG4A gene. Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Its preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. It has also activity of the delipidating enzyme for the PE-conjugated forms.

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

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