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Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.; Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis.; Isoform C is proteolytically inactive.
Gene References into Functions
Caspase-10 is a negative regulator of cell death and a facilitator of gene induction separates the function of cFLIP and caspase-10 in the death-inducing signaling complex. PMID: 28445729
This study reveals an essential role of SUMOylated FADD in Drp1- and caspase-10-dependent necrosis. PMID: 27799292
Three cases of autoimmune lymphoproliferative syndrome due to somatic FAS mutation (ALPS-sFAS) combined with a germline CASP10 variation have been described. PMID: 26323380
Results showed miR-221/222 promote cell proliferation and repress apoptosis, through suppressing caspase-10, in prostate cancer cells. PMID: 26164758
Single nucleotide polymorphisms in CASP10 gene is associated with gastric cancer. PMID: 23921907
While myeloma cells require a basal level of autophagy for survival, caspase-10 tempers this response to avoid cell death. PMID: 23541952
This meta-analysis suggests that the rs13006529 T carrier in the CASP-10 gene might be a risk factor for cancer susceptibility, especially for breast cancer. PMID: 23212337
The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling. PMID: 22782902
induces apoptosis in avian virus H5N1-infected human monocyte-derived macrophages PMID: 21911414
Caspase-10 expression, measured by quantitative real-time RT-PCR, is a possible prognostic factor in patients with stage II colorectal cancer. PMID: 21559821
Caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis. PMID: 21368896
The CASP10 V410I polymorphism was not associated with breast or ovarian cancer risk for BRCA1 or BRCA2 mutation carriers. PMID: 20978178
Data show that caspase-10 is the most active caspase in apoptotic erythroid progenitors induced by 11 kDa and NS1 as well as during B19V infection. PMID: 19861680
Somatic mutation of CASP10 is rare in colon, breast, lung, and hepatocellular carcinomas. PMID: 20025484
CASP10 mutation might contribute to the pathogenesis of factions of T-acute lymphoblastic leukaemia and multiple myeloma. PMID: 19900088
inactivating mutations in non-hodgkin lymphoma. PMID: 12010812
Caspase-10 is recruited to & activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8. Caspase-10 is cleaved during CD95-induced apoptosis of activated T cells. PMID: 12198154
histone H3 phosphoacetylation at the CASPASE-10 gene may play an important role in the induction of apoptosis in acute promyelocytic leukemia cells in response to arsenic trioxide PMID: 12388546
over-expression of GRB2 and FLICE2 in RA synovium is caused by TNF-alpha inducibility differentially regulated in RA synoviocytes and provide potential pathogenic roles of these genes in the hyperplasia of the RA synovium. PMID: 14687710
CASP10 levels are increased following DNA damage in a p53-dependent manner. PMID: 14688482
Re molecular requirements for neutrophil apoptosis: TNF-alpha-mediated apoptosis depends on the activation of caspase-8, spontaneous apoptosis requires the activation of caspase-10/b. PMID: 14761933
taxol induces FADD-dependent apoptosis primarily through activation of caspase-10 but independently of death receptors PMID: 15452117
a model in which caspase-10 is a crucial component during TRAIL-mediated apoptosis PMID: 15767684
Role of variants of caspase-10 in Autoimmune Lymphoproliferative Syndrome. PMID: 16446975
Altogether, these data indicate an active role for caspase-10 in cytotoxic drug-induced tumor cell death, downstream of the mitochondria. PMID: 16767158
These results suggest that caspase-10, DR-3 and IGFBP-3 are involved in apoptosis in the preeclamptic placenta. PMID: 17085968
A novel prodomain-only isoform of caspase-10 may preferentially play a regulatory role in NF-kappa B pathways. PMID: 17822854
Fas expression was reduced and caspase-10 activity was decreased in both patients PMID: 17999750
Caspase-10 expression was down-regulated in both rectal adenomas and cancers PMID: 18716417
Single nucleotide polymorphism data suggest a role for CASP10 as a potential modifier of the asthma phenotype, specifically with measures of airway obstruction and bronchial hyperresponsiveness. PMID: 18823309
the effect of the ectopic expression of the human initiator caspases-10 in Saccharomyces cerevisiae PMID: 19166881
Results show that heat shock protein 90 beta is cleaved by activated caspase-10 under UVB irradiation. PMID: 19380486