CDH1 Antibody

Datasheet
Code CSB-PA795479
Product Type Polyclonal Antibody
Former Code(s) CSB-PA947588
Size US$297
Uniprot No. P12830
Image
  • Western blot analysis of extract from MCF-7 and HT29 cells using E-Cadherin(CD324) Antibody
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Peptide sequence around aa.864~868(E-W-G-N-R) derived from Human E-Cadherin.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous level of total E-Cadherin protein.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin a-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Baki L.et.al(2001)Proc. Natl. Acad. Sci. U.S.A. 98:2381-2386
Makagiansar I.T.et.al(2002)J. Biol. Chem. 277:16002-16010
Agiostratidou G. (2006)J. Neurochem. 96:1182-1188
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality Polyclonal
Alias CDH1; CDHE; UVO
Immunogen Species Homo sapiens (Human)
Target Names CDH1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Cadherins are calcium-dependent cell adhesion proteins
Involvement in disease Hereditary diffuse gastric cancer (HDGC); Endometrial cancer (ENDMC); Ovarian cancer (OC); Breast cancer, lobular (LBC); Blepharocheilodontic syndrome 1 (BCDS1)
Subcellular Location Cell junction, Cell membrane, Single-pass type I membrane protein, Endosome, Golgi apparatus, trans-Golgi network
Tissue Specificity Non-neural epithelial tissues.
Database Links

HGNC: 1748

OMIM: 119580

KEGG: hsa:999

STRING: 9606.ENSP00000261769

UniGene: Hs.461086

Pathway Hippo signaling pathway
Adherens junction
Apelin signaling pathway
Rap1 signaling pathway

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