CDH1 Antibody

Datasheet
Code CSB-PA164023
Size US$299
Uniprot No. P12830
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA164023(CDH1 Antibody) at dilution 1/100, on the right is treated with synthetic peptide. (Original magnification: x200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA164023(CDH1 Antibody) at dilution 1/100, on the right is treated with synthetic peptide. (Original magnification: x200)
  • Gel: 8%SDS-PAGE, Lysate: 40μg, Lane: Human brain malignant glioma tissue, Primary antibody: CSB-PA164023(CDH1 Antibody) at dilution 1/1750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthetic peptide of Human CDH1
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC;ELISA:1:2000-1:10000,WB:1:1000-1:5000,IHC:1:100-1:300
Relevance This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias cadherin 1, type 1, E-cadherin (epithelial)
Immunogen Species Homo sapiens (Human)
Target Names CDH1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Cadherins are calcium-dependent cell adhesion proteins
Involvement in disease Hereditary diffuse gastric cancer (HDGC); Endometrial cancer (ENDMC); Ovarian cancer (OC); Breast cancer, lobular (LBC); Blepharocheilodontic syndrome 1 (BCDS1)
Subcellular Location Cell junction, Cell membrane, Single-pass type I membrane protein, Endosome, Golgi apparatus, trans-Golgi network
Tissue Specificity Non-neural epithelial tissues.
Database Links

HGNC: 1748

OMIM: 119580

KEGG: hsa:999

STRING: 9606.ENSP00000261769

UniGene: Hs.461086

Pathway Hippo signaling pathway
Adherens junction
Apelin signaling pathway
Rap1 signaling pathway

Related Products

CDH1 Antibodies

CDH1 Antibodies for Homo sapiens (Human)

CDH1 Antibodies for Human

CDH1 Proteins

CDH1 Proteins for Homo sapiens (Human)

CDH1 ELISA Kit

CDH1 ELISA Kit for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.