CNTFR Antibody

Code CSB-PA204475
Size US$297
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  • Gel: 10%SDS-PAGE Lysate: 40 ug Mouse skeletal muscle tissue lysate Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 60 seconds

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CNTFR Polyclonal antibody
Uniprot No.
Target Names
CNTFR
Alternative Names
Ciliary neurotrophic factor receptor alpha antibody; Ciliary neurotrophic factor receptor antibody; Ciliary neurotrophic factor receptor subunit alpha antibody; CNTF Receptor alpha antibody; CNTF receptor subunit alpha antibody; CNTFR Alpha antibody; CNTFR antibody; CNTFR-alpha antibody; CNTFR_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein corresponding to a region derived from 23-342 amino acids of Human ciliary neurotrophic factor receptor
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Supplied at 0.5mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1.
Gene References into Functions
  1. The family-based study showed no association between the CNTFR rs7036351, NET rs3785143 polymorphisms, and attention-deficit hyperactivity disorder. PMID: 24565995
  2. gene expression and surface expression in NK92 cells of ciliary neurotrophic factor alpha (CNTFR-alpha) and glycoprotein (gp)130 in natural killer (NK) cells, in the context of malaria, were investigated. PMID: 23398366
  3. Data indicate that CNTFRalpha plays a role in the formation or maintenance of tumor-initiating cells in gliomas, is a marker that correlates with histological grade, may underlie treatment resistance in some cases, and is a potential therapeutic target. PMID: 23061382
  4. expression of neurotrophin receptors Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth. PMID: 22343487
  5. Data show that variants in CNTFR were significantly associated with a lower age at onset of the eating disorders. PMID: 20219210
  6. interactions of CNTFR with LIFR and gp130 in vitro PMID: 12707266
  7. C174T polymorphism in exon 9 of CNTFR is significantly associated with fat-free mass in men and women, with concomitant differences in muscular strength. PMID: 12807897
  8. Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
  9. In liver CNTFRalpha serves as a key modulator in regulating PI3K and AMP-activated protein kinase dynamically under CNTF stimulation, resulting in the increase of glucose uptake and translocation of glucose transporter 4. PMID: 18307269
  10. These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. PMID: 19386761

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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Protein Families
Type I cytokine receptor family, Type 3 subfamily
Tissue Specificity
Nervous system and skeletal muscle.
Database Links

HGNC: 2170

OMIM: 118946

KEGG: hsa:1271

STRING: 9606.ENSP00000242338

UniGene: Hs.129966

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