CNTFR Antibody

Datasheet

Code	CSB-PA005684EA01HU
Size	US$166
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Image	Immunofluorescence staining of SH-SY5Y cells with CSB-PA005684EA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). Western blot All lanes: CNTFR antibody at 2µg/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 41 kDa Observed band size: 41 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005684EA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA005684EA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CNTFR Polyclonal antibody

Uniprot No.

P26992

Target Names

CNTFR

Alternative Names

Ciliary neurotrophic factor receptor alpha antibody; Ciliary neurotrophic factor receptor antibody; Ciliary neurotrophic factor receptor subunit alpha antibody; CNTF Receptor alpha antibody; CNTF receptor subunit alpha antibody; CNTFR Alpha antibody; CNTFR antibody; CNTFR-alpha antibody; CNTFR_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ciliary neurotrophic factor receptor subunit alpha protein (106-342AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CNTFR Antibody (Product code: CSB-PA005684EA01HU) is Non-conjugated. For CNTFR Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA005684EB01HU	CNTFR Antibody, HRP conjugated	ELISA
FITC	CSB-PA005684EC01HU	CNTFR Antibody, FITC conjugated
Biotin	CSB-PA005684ED01HU	CNTFR Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1.

Gene References into Functions

The family-based study showed no association between the CNTFR rs7036351, NET rs3785143 polymorphisms, and attention-deficit hyperactivity disorder. PMID: 24565995
gene expression and surface expression in NK92 cells of ciliary neurotrophic factor alpha (CNTFR-alpha) and glycoprotein (gp)130 in natural killer (NK) cells, in the context of malaria, were investigated. PMID: 23398366
Data indicate that CNTFRalpha plays a role in the formation or maintenance of tumor-initiating cells in gliomas, is a marker that correlates with histological grade, may underlie treatment resistance in some cases, and is a potential therapeutic target. PMID: 23061382
expression of neurotrophin receptors Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth. PMID: 22343487
Data show that variants in CNTFR were significantly associated with a lower age at onset of the eating disorders. PMID: 20219210
interactions of CNTFR with LIFR and gp130 in vitro PMID: 12707266
C174T polymorphism in exon 9 of CNTFR is significantly associated with fat-free mass in men and women, with concomitant differences in muscular strength. PMID: 12807897
Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. PMID: 16782820
In liver CNTFRalpha serves as a key modulator in regulating PI3K and AMP-activated protein kinase dynamically under CNTF stimulation, resulting in the increase of glucose uptake and translocation of glucose transporter 4. PMID: 18307269
These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. PMID: 19386761

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Families

Type I cytokine receptor family, Type 3 subfamily

Tissue Specificity

Nervous system and skeletal muscle.

Database Links

HGNC: 2170

OMIM: 118946

KEGG: hsa:1271

STRING: 9606.ENSP00000242338

UniGene: Hs.129966

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Jak-STAT signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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