CREBBP Antibody

Datasheet
Code CSB-PA824713
Former Code(s) CSB-PA228141
Size US$299
Uniprot No. Q92793
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA824713(CREBBP Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA824713(CREBBP Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: ×200)
Immunogen Synthetic peptide of Human CREBBP
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC;ELISA:1:500-1:5000,IHC:1:5-1:20
Relevance This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias CREB binding protein
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Target Names CREBBP
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators
Involvement in disease Rubinstein-Taybi syndrome 1 (RSTS1)
Subcellular Location Cytoplasm, Nucleus
Database Links

HGNC: 2348

OMIM: 180849

KEGG: hsa:1387

STRING: 9606.ENSP00000262367

UniGene: Hs.459759

Pathway cAMP signaling pathway
HIF-1 signaling pathway
Jak-STAT signaling pathway
Melanogenesis
Notch signaling pathway
TGF-beta signaling pathway
Wnt signaling pathway
Adherens junction
Cell cycle
FoxO signaling pathway
Glucagon signaling pathway

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