CREBBP, a gene with significant nuclear expression, is integral to physiological processes including embryonic development, growth control, and homeostasis, through its interactions with various transcription factors. The CREBBP-encoded protein exhibits histone acetyltransferase activity, modulating gene transcription by acetylating histones and non-histone proteins. It also acts as a scaffold, stabilizing interactions with other proteins and facilitating the assembly of transcription complexes, which are vital for cellular function and cell cycle regulation. Mutations in CREBBP can result in Rubinstein-Taybi syndrome(RTS) and are linked to acute myeloid leukemia, underscoring its role in developmental biology and disease. Overall, CREBBP's influence on gene regulation and cellular balance is pivotal, marking it as a critical component in the genetics of health and disease.
Recombinant Human CREB-binding protein (CREBBP), partial (CSB-EP838805HU1)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CREBBP Antibody (CSB-PA838805LA01HU)
Validated Data
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA838805LA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA838805LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following CREBBP reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CREBBP Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA027631 | CREBBP Antibody | Human,Mouse,Rat | ELISA, WB, IHC, IF |
CSB-PA901849 | CREBBP Antibody | Human,Mouse | ELISA,WB,IHC,IF |
CSB-PA000107 | Acetyl-CREBBP (K1535) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA001358 | CREBBP Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA001359 | CREBBP Antibody | Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA824713 | CREBBP Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA838805LA01HU | CREBBP Antibody | Human | ELISA, IHC, IF |
CREBBP Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP005954MO CSB-EP005954MO CSB-BP005954MO CSB-MP005954MO CSB-EP005954MO-B |
Recombinant Mouse CREB-binding protein (Crebbp), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CREBBP Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP757128RA CSB-EP757128RA CSB-BP757128RA CSB-MP757128RA CSB-EP757128RA-B |
Recombinant Rat CREB-binding protein (Crebbp), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CREBBP Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP838805HU CSB-EP838805HU CSB-BP838805HU CSB-MP838805HU CSB-EP838805HU-B |
Recombinant Human CREB-binding protein (CREBBP), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP838805HU1 | Recombinant Human CREB-binding protein (CREBBP), partial | E.coli |