CREBBP Antibody

Datasheet
Code CSB-PA027631
Product Type Polyclonal Antibody
Size US$295
Uniprot No. Q92793
Image
  • Western blot analysis on HeLa cell lysate using CBP Antibody
Immunogen A synthesized peptide derived from Human CBP
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity CBP Antibody detects endogenous levels of CBP
Tested Applications ELISA,WB,IHC,IF/ICC;WB:1:500-1:2000,IHC:1:50-1:200,IF/ICC:1:100-1:500
Relevance

CBP a protein acetyltransferase that can transcriptionally activate histones. Acetylates the NCOA3 coactivator. Binds specifically to phosphorylated CREB1 and enhances its transcriptional activity toward cAMP-responsive genes. Methylation of the KIX domain by CARM1 blocks association with CREB, blocking CREB signaling, and activating the apoptotic response. Found in a complex containing NCOA2, NCOA3, IKKA, IKKB, and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with the C-terminal region of CITED4. The TAZ-type 1 domain interacts with HIF1A. Interacts with MAF, SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with HTLV-1 Tax, p30II, and HIV-1 Tat. Interacts with KLF1; 

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Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antigen Affinity Purified
Clonality Polyclonal
Alias CBP; CREB binding protein; CREB-binding protein; CREBBP; KAT3A; RSTS
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Target Names CREBBP
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators
Involvement in disease Rubinstein-Taybi syndrome 1 (RSTS1)
Subcellular Location Cytoplasm, Nucleus
Database Links

HGNC: 2348

OMIM: 180849

KEGG: hsa:1387

STRING: 9606.ENSP00000262367

UniGene: Hs.459759

Pathway cAMP signaling pathway
HIF-1 signaling pathway
Jak-STAT signaling pathway
Melanogenesis
Notch signaling pathway
TGF-beta signaling pathway
Wnt signaling pathway
Adherens junction
Cell cycle
FoxO signaling pathway
Glucagon signaling pathway

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