CREBBP Antibody

Datasheet
Code CSB-PA838805LA01HU
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Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q92793
Image
  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA838805LA01HU at dilution of 1:100

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA838805LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunogen Recombinant Human CREB-binding protein (2217-2442AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200
Relevance Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias CREB-binding protein (EC 2.3.1.48), CREBBP, CBP
Immunogen Species Human
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names CREBBP
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators
Involvement in disease Rubinstein-Taybi syndrome 1 (RSTS1)
Subcellular Location Cytoplasm, Nucleus
Database Links

HGNC: 2348

OMIM: 180849

KEGG: hsa:1387

STRING: 9606.ENSP00000262367

UniGene: Hs.459759

Pathway cAMP signaling pathway
HIF-1 signaling pathway
Jak-STAT signaling pathway
Melanogenesis
Notch signaling pathway
TGF-beta signaling pathway
Wnt signaling pathway
Adherens junction
Cell cycle
FoxO signaling pathway
Glucagon signaling pathway

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