DNAJC19 Antibody

Code CSB-PA007026GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DNAJC19
Alternative Names
DnaJ (Hsp40) homolog; subfamily C; member 19 antibody; DnaJ homolog subfamily C member 19 antibody; DNAJC19 antibody; homolog of yeast TIM14 antibody; Mitochondrial import inner membrane translocase subunit TIM14 antibody; PAM18 antibody; TIM 14 antibody; TIM14 antibody; TIM14_HUMAN antibody; TIMM 14 antibody; TIMM14 antibody; translocase of the inner mitochondrial membrane 14 antibody; Translocase of the inner mitochondrial membrane 14; yeast homolog of antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human DNAJC19
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling. May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.
Gene References into Functions
  1. Both DnaJC15 and DnaJC19 formed two distinct subcomplexes with Magmas at the import channel. PMID: 27330077
  2. The loss of DNAJC19/PHB complexes affects cardiolipin acylation and leads to the accumulation of cardiolipin species with altered acyl chains. PMID: 24856930
  3. A report of a new mutation in the human DNAJC19 gene that causes early onset dilated cardiomyopathy syndrome in two brothers of Finnish origin. PMID: 22797137
  4. The association of dilated cardiomyopathy with ataxia (DCMA) syndrome with a segment of 3q26.33 and the identification of a splice mutation in a novel gene DNAJC19 in DCMA patients. PMID: 16055927
  5. Dilated cardiomyopathy caused by homozygous mutations in a novel gene, DNAJC19, presumed to play a role in importation of mitochondrial proteins. PMID: 17244376

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Involvement in disease
3-methylglutaconic aciduria 5 (MGA5)
Subcellular Location
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein Families
TIM14 family
Tissue Specificity
Ubiquitously expressed.
Database Links

HGNC: 30528

OMIM: 608977

KEGG: hsa:131118

STRING: 9606.ENSP00000372005

UniGene: Hs.230601

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