EDEM1 Antibody, FITC conjugated

Datasheet
Code CSB-PA838793LC01HU
Size US$299
Uniprot No. Q92611
Protocols ELISA Protocol
Immunogen Recombinant Human ER degradation-enhancing alpha-mannosidase-like protein 1 protein (46-128AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias ER degradation-enhancing alpha-mannosidase-like protein 1, EDEM1, EDEM KIAA0212
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names EDEM1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.
Subcellular Location Endoplasmic reticulum membrane, Single-pass type II membrane protein
Protein Families Glycosyl hydrolase 47 family
Database Links

HGNC: 18967

OMIM: 607673

KEGG: hsa:9695

STRING: 9606.ENSP00000256497

UniGene: Hs.224616

Pathway Protein processing in endoplasmic reticulum
Cell ageing and metabolism

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