EDEM1 Antibody

1. EDEM1 colocalizes with the selective autophagy cargo receptors p62/SQSTM1, neighbor of BRCA1 gene 1 (NBR1) and autophagy-linked FYVE (Alfy) protein, and becomes engulfed by autophagic isolation membranes. PMID: 24664425
2. Endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation. PMID: 25132672
3. miR-581 promotes hepatitis B virus surface antigen expression by targeting Dicer and EDEM1 in HepG2 cells. PMID: 24913918
4. EDEM1 associates with lifespan in animal models, although not humans. PMID: 24037343
5. analysis of a shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins PMID: 23233672
6. Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region PMID: 22905195
7. we suggest that a nascent glycoprotein can normally dissociate from EDEM1 and be rescued from endoplasmic reticulum associated degradation by reentering calnexin-refolding cycles PMID: 21917589
8. signal sequence cleavage functionally regulated the association of EDEM1-soluble and membrane-integrated isoforms with distinct ERAD machinery and substrates. PMID: 21632540
9. EDEM1 protein recognition may be determined by the structure of the endoplasmic reticulum-associated protein degradation substrate in a study of mutant ricin A-chain transport to the cytosol. PMID: 21388347
10. mannose trimming enables delivery of a substrate glycoprotein from EDEM1 to late endoplasmic reticulum degredation steps through association with XTP3-B PMID: 21062743
11. The EDEM1 activity trims mannose from the C branch of N-glycans in vivo. PMID: 20065073
12. EDEM1 promotes correct folding and enhanced degradation of rod opsin. PMID: 19934218
13. EDEM was shown to extract misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle [EDEM] PMID: 12610306
14. EDEM1 is a soluble protein of the ER lumen in HEK293 cells PMID: 15579471
15. These results indicate that EDEM may maintain the retrotranslocation competence of NHK by inhibiting aggregation so that unstable misfolded proteins can be accommodated by the dislocon for ERAD. PMID: 16629899
16. the endoplasmic reticulum quality control vesicular transport pathway using EDEM1 does not involve the COPII exit sites PMID: 17360537
17. Cells with defective EDEM1 turnover contain unphysiologically high levels of EDEM1, show enhanced ER associated degradation activity and are characterized by impaired capacity to efficiently complete maturation of model glycopolypeptides. PMID: 18452703
18. endogenous EDEM1 in cells not stressed by the expression of a transgenic misfolded protein reaches the cytosol and is degraded by basal autophagy PMID: 19266160
19. EDEM1 specifically binds nonnative proteins in a glycan-independent manner. PMID: 19524542

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HGNC: 18967

OMIM: 607673

KEGG: hsa:9695

STRING: 9606.ENSP00000256497

UniGene: Hs.224616