EIF4E2 Antibody

Code CSB-PA007558ESR1HU
Size US$166
Order now
Image
  • Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA007558ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007558ESR1HU at dilution of 1:100

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EIF4E2 Polyclonal antibody
Uniprot No.
Target Names
EIF4E2
Alternative Names
4E LP antibody; 4EHP antibody; 4ELP antibody; EIF 4E type 2 antibody; eIF-4E type 2 antibody; EIF4 E2 antibody; EIF4E 2 antibody; eIF4E family; member 2 antibody; EIF4E HOMOLOGOUS PROTEIN antibody; EIF4E like cap binding protein antibody; EIF4E like protein 4E LP antibody; EIF4E like protein 4ELP antibody; eIF4E type 2 antibody; EIF4E type 3 antibody; eIF4E-like 3 antibody; eIF4E-like protein 4E-LP antibody; EIF4E2 antibody; Eukaryotic translation initiation factor 4E family member 2 antibody; Eukaryotic translation initiation factor 4E homologous protein antibody; Eukaryotic translation initiation factor 4E like 3 antibody; Eukaryotic translation initiation factor 4E member 2 antibody; Eukaryotic translation initiation factor 4E type 2 antibody; Eukaryotic translation initiation factor 4E-like 3 antibody; IF 4e antibody; IF4E antibody; IF4E2_HUMAN antibody; mRNA cap binding protein 4EHP antibody; mRNA cap binding protein type 3 antibody; mRNA cap-binding protein 4EHP antibody; mRNA cap-binding protein type 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Eukaryotic translation initiation factor 4E type 2 protein (1-240AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression.
Gene References into Functions
  1. cadherin-22 is upregulated in hypoxia via mTORC1-independent translational control by the initiation factor eIF4E2 functioning as a hypoxia-specific cell-surface molecule involved in cancer cell migration, invasion and adhesion. PMID: 28991229
  2. cap-binding activity contributes to the translational silencing by miRNAs through the CCR4-NOT complex PMID: 28487484
  3. We performed bioinformatics analyses of ESTs and the 3'UTRs of the main transcript splice variants of the translational initiation factor eIF4E1 and its family members, eIF4E2 and eIF4E3. We propose to elucidate the minor splice variants of eIF4E2 and eIF4E3 in great detail because they might produce proteins with modified features that fulfill different cellular roles from their major counterparts. PMID: 28942592
  4. miRNA enhances eIF4E2 association with the target mRNA PMID: 28755203
  5. Following heat shock, eIF4E2 is found in both processing bodies and stress granules, whereas eIF4E3_A relocates only to stress granules. PMID: 27578149
  6. Tristetraprolin recruits eukaryotic initiation factor 4E2 (eIF4E2) to repress target mRNA translation. PMID: 26370510
  7. DNA damage induces an increase in ARIH1 protein levels and association of ARIH1 with 4EHP. In turn, this causes 4EHP recruitment to the mRNA cap, where it is known to compete with eIF4E. PMID: 25624349
  8. provide evidence that eIF4E2 binds 4E-T in the yeast two hybrid assay, as well as in pull-down assays and by recruitment to P-bodies in mammalian cells PMID: 23991149
  9. Activation of eIF4E2-directed translation is essential for cancer cells. PMID: 24408918
  10. GIGYF2 and the zinc finger protein 598 (ZNF598) are identified as components of the 4EHP complex. PMID: 22751931
  11. 4EHP over-expression instigates a negative feedback loop that inhibits upstream signaling to 4E-BP1 and ribosomal protein S6 kinase 1 (S6K1) whereas the 4E-BP1-binding-deficient mutant of 4EHP(W95A) was unable to trigger this feedback loop PMID: 15094042
  12. ISGylation of 4EHP may play an important role in cap structure-dependent translation control in immune responses. PMID: 17289916
  13. 4EHP plays a physiological role utilizing both cap-binding and protein-binding functions but which is distinct from eIF4E. PMID: 17368478
  14. 4EHP binds cap analogs m(7)GpppG and m(7)GTP with low affinity PMID: 17369309

Show More

Hide All

Subcellular Location
Cytoplasm. Cytoplasm, P-body.
Protein Families
Eukaryotic initiation factor 4E family
Database Links

HGNC: 3293

OMIM: 605895

KEGG: hsa:9470

STRING: 9606.ENSP00000258416

UniGene: Hs.292026

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*