FBP1 Antibody

Datasheet
Code CSB-PA825632
Size US$299
Uniprot No. P09467
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA825632(FBP1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA825632(FBP1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Mouse stomach tissue, human fetal liver tissue, MCF7 cells, mouse liver tissue tissue, Primary antibody: CSB-PA825632(FBP1 Antibody) at dilution 1/850, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Fusion protein of Human FBP1
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,WB,IHC;ELISA:1:2000-1:10000,WB:1:1000-1:5000,IHC:1:50-1:200
Relevance Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias fructose-1,6-bisphosphatase 1
Immunogen Species Homo sapiens (Human)
Target Names FBP1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Involvement in disease Fructose-1,6-bisphosphatase deficiency (FBP1D)
Protein Families FBPase class 1 family
Tissue Specificity Expressed in pancreatic islets.
Database Links

HGNC: 3606

OMIM: 229700

KEGG: hsa:2203

STRING: 9606.ENSP00000364475

UniGene: Hs.494496

Pathway AMPK signaling
Glucagon signaling pathway
Insulin signaling pathway

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